血清唾液酸对肺、胃、肠癌治疗监测的意义

Significance of serum sialic acid in monitoring the treatment of lung,stomach and colorectal cancer

目的研究血清唾液酸(SA)对肺、胃、肠癌治疗监测的意义。方法选取在本院申请生化检测项目并按疗程完成化疗的肺癌(45例)、胃癌(44例)、肠癌(47例)患者136例作为恶性肿瘤组,选取同期在本院申请生化检测项目的体检健康人群100例为参照组。两组研究对象均给予血清SA监测。对比两组研究对象的血清SA水平及血清SA阳性率,恶性肿瘤组病情好转及恶化患者治疗前后的血清SA水平。结果恶性肿瘤组患者的平均血清SA水平及肺、胃、肠癌患者的血清SA水平分别为(84.63±16.38)、(88.79±17.24)、(85.36±16.48)、(82.34±16.11)mg/dl,均高于参照组的(56.32±7.46)mg/dl,差异具有统计学意义(P<0.05)。恶性肿瘤组患者的总血清SA阳性率及肺、胃、肠癌患者的血清SA阳性率分别为79.41%、80.00%、79.55%、78.72%,均高于参照组的0,差异具有统计学意义(P<0.05)。治疗后,恶性肿瘤组患者病情好转112例,病情恶化24例。病情好转患者治疗后的血清SA水平低于治疗前及病情恶化患者治疗后,差异具有统计学意义(P<0.05)。结论对肺、胃、肠癌患者给予血清SA监测,可评估患者病情变化情况,并对疗效、预后进行判断,且具有一定的阳性检出率,值得借鉴。

Objective To study the significance of serum sialic acid(SA)in monitoring the treatment of lung,stomach and colorectal cancer.Methods Patients with lung cancer(45 cases),gastric cancer(44 cases)and intestinal cancer(47 cases)who applied for the biochemical testing program in our hospital and completed chemotherapy according to the treatment course were selected as the malignant tumor group,and 100 healthy subjects who applied for the biochemical testing program in our hospital at the same time were selected as the reference group.Serum SA was monitored in both groups.The serum SA levels and serum SA positivity rates of the study subjects in both groups were compared,and the serum SA levels of patients with improvement and deterioration in the malignant tumor group were compared before and after treatment.Results The mean serum SA levels of patients in the malignant tumor group and patients with lung,stomach and colorectal cancer were(84.63±16.38),(88.79±17.24),(85.36±16.48)and(82.34±16.11)mg/dl,respectively,which were higher than(56.32±7.46)mg/dl of the reference group,and the differences were statistically significant(P<0.05).The serum SA positivity rates of patients in the malignant tumor group and patients with lung,stomach and colorectal cancer were 79.41%,80.00%,79.55%and 78.72%,respectively,which were higher than 0 of the reference group,and the difference was statistically significant(P<0.05).After treatment,112 cases improved and 24 cases deteriorated in the malignant tumor group.The serum SA level of patients with improvement after treatment was lower than that before treatment and patients with deterioration after treatment,and the difference was statistically significant(P<0.05).Conclusion Serum SA monitoring of lung,stomach and colorectal cancer can evaluate the changes of patients’condition,and judge the efficacy and prognosis.It has a certain positive detection rate,which is worthy of reference.