门冬胰岛素30联合二甲双胍治疗老年初诊2型糖尿病的临床疗效

Clinical efficacy of insulin aspart 30 combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus in the elderly

目的探讨对老年初诊2型糖尿病患者使用门冬胰岛素30联合二甲双胍治疗的效果。方法50例老年初诊2型糖尿病患者作为研究对象,按照随机数字表法分为实验组与对照组,每组25例。对照组患者给予门冬胰岛素30皮下注射治疗,实验组患者在对照组基础上联合二甲双胍治疗。对比两组患者治疗效果、血糖指标水平及血脂指标水平。结果治疗后,实验组总有效率96.00%明显高于对照组的76.00%,差异具有统计学意义(P<0.05)。治疗后,实验组患者餐后2 h血糖为(8.04±0.37)mmol/L、空腹血糖为(5.62±0.51)mmol/L、糖化血红蛋白为(6.08±1.03)%,均低于对照组的(10.56±1.06)mmol/L、(6.41±1.26)mmol/L、(8.14±0.71)%,差异具有统计学意义(P<0.05)。治疗后,实验组患者甘油三酯为(1.51±0.72)mmol/L、总胆固醇为(4.57±0.98)mmol/L、低密度脂蛋白胆固醇为(3.05±0.74)mmol/L,均低于对照组的(2.71±0.84)、(5.46±1.04)、(3.64±0.87)mmol/L,高密度脂蛋白胆固醇(1.24±0.29)mmol/L高于对照组的(0.87±0.32)mmol/L,差异具有统计学意义(P<0.05)。结论老年初诊2型糖尿病患者使用门冬胰岛素30联合二甲双胍治疗可以有效提高治疗效果,降低患者的血糖、血脂。

Objective To discuss the effect of insulin aspart 30 combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus in the elderly.Methods A total of 50 elderly patients with newly diagnosed type 2 diabetes mellitus were studied and divided into experimental group and control group,with 25 cases in each group.Patients in the control group were treated with subcutaneous injection of insulin aspart 30,and patients in the experimental group were treated with metformin on the basis of the control group.Patients in both groups were compared in terms of therapeutic effect,blood glucose indicators and blood lipid indicators.Results After treatment,the total effective rate 96.00%in the experimental group was significantly higher than 76.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the 2 h postprandial glucose(8.04±0.37)mmol/L,fasting blood glucose(5.62±0.51)mmol/L,and glycosylated hemoglobin(6.08±1.03)%of the experimental group were lower than(10.56±1.06)mmol/L,(6.41±1.26)mmol/L and(8.14±0.71)%of the control group,and the difference was statistically significant(P<0.05).After treatment,the triglycerides(1.51±0.72)mmol/L,total cholesterol(4.57±0.98)mmol/L and low-density lipoprotein cholesterol(3.05±0.74)mmol/L of the experimental group were lower than(2.71±0.84),(5.46±1.04)and(3.64±0.87)mmol/L of the control group,and the high-density lipoprotein cholesterol(1.24±0.29)mmol/L was higher than(0.87±0.32)mmol/L of the control group.All the differences were statistically significant(P<0.05).Conclusion Combination of insulin aspart 30 and metformin can improve the therapeutic effect of elderly patients with newly diagnosed type 2 diabetes mellitus,and lower the blood glucose and blood lipid of patients.