镇肝熄风汤加减方联合厄贝沙坦治疗肝阳上亢型高血压的效果探讨

Discussion on effect of modified Zhengan Xifeng Decoction combined with irbesartan in the treatment of hypertension of liver-yang hyperactivity type

目的探讨肝阳上亢型高血压患者应用镇肝熄风汤加减方联合厄贝沙坦治疗的临床效果。方法76例肝阳上亢型高血压患者,采用随机数字表法分为对照组和观察组,各38例。对照组患者采用厄贝沙坦治疗,观察组患者在对照组基础上联合镇肝熄风汤加减方治疗。对比两组患者治疗前后血压水平、临床疗效及不良反应发生率。结果治疗前,两组收缩压(SBP)、舒张压(DBP)对比差异无统计学意义(P>0.05);治疗后,两组SBP、DBP均低于治疗前,且观察组SBP(133.16±2.05)mm Hg(1 mm Hg=0.133 kPa)、DBP(72.06±2.15)mm Hg均低于对照组的(141.95±3.18)、(81.63±3.22)mm Hg,差异有统计学意义(P<0.05)。观察组总有效率97.37%高于对照组的84.21%,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.26%,与对照组的15.79%对比差异无统计学意义(P>0.05)。结论对于肝阳上亢型高血压患者给予镇肝熄风汤加减方联合厄贝沙坦进行治疗可获得满意疗效,能够明显改善患者的血压水平,同时用药安全性良好。

Objective To discuss the clinical effect of modified Zhengan Xifeng Decoction combined with irbesartan in the treatment of hypertension of liver-yang hyperactivity type.Methods A total of 76 patients with hypertension of liver-yang hyperactivity type were divided into control group and observation group according to random numerical table,with 38 cases in each group.The control group was treated with irbesartan,and the observation group was treated with modified Zhengan Xifeng Decoction based on the control group.The blood pressure before and after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in SBP and DBP between the two groups(P>0.05).After treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the two groups were lower than those before treatment,and the SBP(133.16±2.05)mm Hg(1 mm Hg=0.133 kPa)and DBP(72.06±2.15)mm Hg of the observation group were lower than(141.95±3.18)and(81.63±3.22)mm Hg of the control group;all the difference was statistically significant(P<0.05).The total effective rate of the observation group was 97.37%,which was higher than 84.21%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 5.26%,which had no statistically significant difference compared with 15.79%of the control group(P>0.05).Conclusion Combination of modified Zhengan Xifeng Decoction and irbesartan has satisfactory efficacy on patients with hypertension of liver-yang hyperactivity type,and it can obviously improve the blood pressure of patients with high drug safety.