脾虚浊毒论

The theory of turbidity-toxin induced by spleen deficiency

浊毒理论是国医大师李佃贵教授提出的创新性理论。目前,浊毒理论的研究重点在于浊毒的致病特性和因浊毒所演发的病理改变,对于浊毒形成的条件性及内生性尚未形成系统化认识。文章立足于脏腑观,以脾脏的生理功能、病理改变为基,以现代研究热点免疫功能、人体微生态为切入点,从"脾虚-肠道菌群失调/免疫功能障碍-浊毒"动态病机演变探讨浊毒生成之源,阐明浊毒产生及浊毒致病的条件性,归纳脾虚生浊成毒的致病特性,完善浊毒的病机内涵。脾虚浊毒论是浊毒理论的补充与完善,为浊毒理论的进一步研究提供新思路。

The turbidity-toxin theory is an innovative theory put forward by Professor Li Diangui, a master of traditional Chinese medicine. At present, the research of turbidity-toxin theory mainly focuses on the pathogenic characteristics of turbidity-toxin and the pathological changes caused by turbidity-toxin. However, there is no systematic understanding of the condition and endogenous nature of the formation of turbidity-toxin. Based on the theory of the zang-fu organs and the physiological function and pathological changes of spleen, and in view of the hotspots of immune function and human micro-ecology in modern research, this paper discusses the origin of turbidity-toxin from the perspective of dynamic pathogenesis evolution from spleen deficiency to intestinal flora imbalance or immune dysfunction and to turbidity-toxin, clarifies the conditions for the formation and pathogenicity of turbidity-toxin, and summarizes the pathogenic characteristics of spleen deficiency induced turbidity-toxin, improving the understanding of the pathogenesis of turbidity-toxin. The theory of turbidity-toxin induced by spleen deficiency complements and develops the turbidity-toxin theory, providing new ideas for further study of the latter.