血府逐瘀汤联合西药治疗冠心病不稳定型心绞痛临床研究

Clinical Study of Xuefu Zhuyu Tang Combined with Western Medicine for Unstable Angina Pectoris of Coronary Heart Disease

目的:观察血府逐瘀汤联合西药治疗冠心病不稳定型心绞痛的临床疗效及对抗氧化能力、血清基质金属蛋白酶-6 (MMP-6)、基质金属蛋白酶-9 (MMP-9)的影响。方法:选取74例冠心病不稳定心绞痛患者作为研究对象,按随机数字表法分为研究组及对照组各37例。2组均进行基础对症治疗,研究组在此基础上加用血府逐瘀汤,2组均连续治疗8周。观察2组临床疗效,比较2组治疗前后中医证候积分及心功能指标[左心室射血分数(LVEF)、左室舒张末期容量(LVEDV)、左室收缩末期容量(LVESV)],比较2组治疗前后血清超氧化物歧化酶(SOD)活性、血清基质金属蛋白酶-6 (MMP-6)含量、基质金属蛋白酶-9 (MMP-9)水平。结果:治疗后,研究总有效率为97.30%,高于对照组83.78%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前降低,研究组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组LVEF指标值均较治疗前上升,2组LVEDV、LVESV指标值均较治疗前下降,差异均有统计学意义(P<0.05);研究组LVEF指标值高于对照组,LVEDV、LVESV指标值低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清SOD水平均较治疗前上升,2组血清MMP-6、MMP-9水平均较治疗前下降,差异均有统计学意义(P<0.05);研究组血清SOD水平高于对照组,血清MMP-6、MMP-9水平均低于对照组,差异均有统计学意义(P<0.05)。结论:血府逐瘀汤联合西药治疗冠心病不稳定型心绞痛可有效提高血液抗氧化能力,对缓解临床症状及改善心功能具有较好的作用。

Objective:To observe the clinical effect of Xuefu Zhuyu tang combined with western medicine for unstable angina pectoris of coronary heart disease and its effect on antioxidant capacity and matrix metalloproteinase-6(MMP-6) and matrix metalloproteinase-9(MMP-9) in serum. Methods: A total of 74 cases of patients with unstable angina pectoris of coronary heart disease were selected as the research objects, and divided into the study group and the control group according to the random number table method, 37 cases in each group. Both groups were given basic symptomatic treatment, and the study group was additionally given Xuefu Zhuyu tang. Both groups were treated for eight weeks. The clinical effects in the two groups were observed. Before and after treatment,Chinese medicine syndrome scores and heart function indexes including left ventricle ejection fraction(LVEF), left ventricular end diastolic volume(LVEDV) and left ventricular end systolic volume(LVESV) in the two groups were compared. Before and after treatment,the activity of plasma superoxide dismutase(SOD), the contents of matrix metalloproteinase-6(MMP-6) in serum and the levels of matrix metalloproteinase-9(MMP-9) in the two groups were compared. Results: After treatment, the total effective rate was97.30% in the study group,higher than that of 83.78% in the control group,the difference being significant(P<0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the study group was lower than that in the control group,differences being significant(P<0.05).After treatment,LVEF values in the two groups were increased when compared with those before treatment,and the values of LVEDV and LVESV were decreased, differences being significant(P<0.05);LVEF value in the study group was significantly higher than that in the control group, and the values of LVEDV and LVESV were lower, differences being significant(P<0.05). After treatment, SOD levels in the two groups were increased when compared with those before treatment,and the levels of MMP-6 and MMP-9 were decreased,differences being significant(P<0.05);SOD level in the study group was higher than that in the control group,and the levels of MMP-6 and MMP-9 were lower,differences being significant(P<0.05). Conclusion: The therapy of Xuefu Zhuyu tang combined with western medicine for unstable angina pectoris of coronary heart disease can effectively improve the blood antioxidant capacity, with a good clinical effect on relieving clinical symptoms and improving heart function.