胺碘酮联合芪参益气滴丸治疗房颤患者转复窦律临床研究

Clinical Study on Amiodarone Combined with Qishen Yiqi Dropping Pills for Atrial Fibrillation Patients in Terms of Restoring Sinus Rhythm

目的:观察胺碘酮与芪参益气滴丸联合应用于房颤患者转复窦律的治疗效果。方法:选取80例房颤患者作为研究对象进行前瞻性研究,采用随机数字表法分为对照组与观察组,各40例。对照组使用胺碘酮治疗,观察组使用胺碘酮联合芪参益气滴丸治疗。对比2组临床疗效、各项临床指标及不良反应发生情况。结果:观察组的转复窦律成功率为92.50%,高于对照组的75.00%(P<0.05)。观察组复律后3个月、6个月及12个月的维持窦律成功率均高于对照组(P<0.05)。与同组治疗前比较,治疗后2组左心房直径均缩短(P<0.05),E峰值、A峰值、E/A比值均升高(P<0.05);与对照组治疗后比较,观察组治疗后左心房直径较短(P<0.05),E峰值、A峰值、E/A比值均较高(P<0.05)。观察组的总不良反应发生率为5.00%,低于对照组的22.50%(P<0.05)。结论:胺碘酮与芪参益气滴丸联合应用治疗房颤患者转复窦律的改善效果明显,可有效减慢心室率且不良反应发生情况较少。

Objective:To observe the clinical effect of the therapy of amiodarone combined with Qishen Yiqi dropping pills on atrial fibrillation patients in terms of restoring sinus rhythm. Methods: A total of 80 patients with atrial fibrillation were selected as subjects for a prospective study,and were divided into the control group and the observation group by random number table method,40 cases in each group. The control group was treated with amiodarone,and the observation group was treated with amiodarone combined with Qishen Yiqi dropping pills. The clinical effect,various clinical indicators and the incidence of adverse reactions were compared between the two groups. Results:The success rate of restoring sinus rhythm in the observation group was 92.50%, higher than that of 75.00% in the control group(P<0.05). The success rate of maintaining sinus rhythm at 3,6 and 12 months after restoration of sinus rhythm in the observation group was respectively higher than that in the control group(P<0.05). Compared with those in the same group before treatment respectively,the left atrial diameter after treatment in the two groups were decreased(P<0.05), and the E peak, A peak, E/A ratio were increased(P<0.05). Compared with those in the control group after treatment respectively, the left atrial diameter in the observation group was shorter(P<0.05), and the E peak, A peak, E/A ratio were larger(P<0.05). The total incidence of adverse reactions in the observation group was 5.00%,lower than that of 22.50% in the control group(P<0.05). Conclusion:The combined application of amiodarone and Qishen Yiqi dropping pills has significant therapeutic effect in treating atrial fibrillation patients in terms of restoring sinus rhythm,which can effectively slow down the ventricular rate and reduce the incidence of adverse reactions.