CT引导下经皮冷冻消融治疗肺磨玻璃结节的研究

CT-guided percutaneous cryoablation for the treatment of pulmonary ground-glass nodules

目的评价CT引导下经皮冷冻消融治疗肺磨玻璃结节的安全性和可行性。方法 2016年6月至2019年11月,28例肺磨玻璃结节患者中有13例为既往肺癌患者,15例为疑是肺肿瘤患者,共35枚结节,平均大小1.04 cm。患者接受了CT引导下同步穿刺活检及经皮冷冻消融,评估冷冻消融后的不良事件、肺功能和治疗效果。使用SPSS 20.0进行统计分析。结果所有患者均未出现严重并发症,10例(35.7%)患者出现气胸,9例(32.1%)出现痰中带血,对症治疗后所有症状均得到缓解,术后1个月肺功能恢复>95%。接受随访36个月的CT断层扫描中,所有患者的肺磨玻璃结节均被成功消融,无复发。结论 CT引导下经皮冷冻消融是治疗肺磨玻璃结节是可行、安全、有效的。

Objective To evaluate the safety and feasibility of CT-guided percutaneous cryoablation for the treatment of pulmonary ground-glass nodules. Methods A total of 28 patients with ground-glass nodule(GGN) of lung, including 13 patients with a history of previous lung cancer and 15 patients with suspected lung tumor, who were admitted to authors’ hospital during the period from June 2016 to November 2019 to receive CT-guided percutaneous biopsy with simultaneous cryoablation, were enrolled in this study. A total of 35 GGN lesions were detected in the 28 patients, the mean diameter of lesions was 1.04 cm. After cryoablation, the adverse events, lung function and therapeutic effect were evaluated. Statistical Package for the Social Sciences software(SPSS 20.0 version) was used to conduct statistical analyses. Results No serious complications occurred in all patients. Ten patients(35.7%) developed pneumothorax and 7(32.1%) patients developed bloody sputum,which were relieved after symptomatic treatment. One month after cryoablation, the recovery degree of lung function was over 95%. CT reexamination performed during the follow-up period of 36 months showed that all the GGN lesions were successfully ablated with no recurrence in all patients. Conclusion For the treatment of pulmonary GNN lesions, CT-guided percutaneous cryoablation is clinically feasible, safe and effective.(J Intervent Radiol, 2021, 30: 1072-1076)