Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension

Results:Of the 9624 patients screened for eligibility,8511 were enrolled in the trial;4243 were randomly assigned to the intensive-treatment group and 4268 to the standard-treatment group.At 1 year of follow-up,the mean systolic blood pressure was 127.5 mm Hg in the intensive-treatment group and 135.3 mm Hg in the standard-treatment group.During a median follow-up period of 3.34 years,primary-outcome events occurred in 147 patients(3.5%)in the intensive-treatment group,as compared with 196 patients(4.6%)in the standard-treatment group(hazard ratio,0.74;95%confidence interval[CI],0.60 to 0.92;P=0.007).The results for most of the individual components of the primary outcome also favored intensive treatment:the hazard ratio for stroke was 0.67(95%CI,0.47 to 0.97),acute coronary syndrome 0.67(95%CI,0.47 to 0.94).