中性粒细胞胞外诱捕网及其在痛风性疾病中的作用

Neutrophil extracellular traps and its role in gouty diseases

中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是机体先天免疫的重要组成部分,主要以NADPH氧化酶2依赖性途径参与痛风性疾病的发生,且与痛风性关节炎自发性缓解及痛风石的形成有关。这些病理性特征可采用电镜技术、免疫组化染色等方法进行分析。为了进一步探究NETs分子机制,发现痛风性关节炎潜在的药物作用靶点,本文就其在痛风性疾病中的作用以及相关的检测技术进行概述。

Neutrophil extracellular traps(NETs)are an important part of the innate immunity.They are mainly involved in the occurrence of gout disease through NADPH oxidase 2-dependent pathways and it is related to the spontaneous remission of gouty arthritis and the formation of tophi.These pathological features can be analyzed by methods such as electron microscopy and immunohistochemical staining.In order to further explore the molecular mechanism of NETs and discover potential drug targets for gouty arthritis,this article summarizes its role in gouty diseases and related detection techniques.