线粒体能量代谢参与抑郁症发病的研究进展

Research progress of mitochondrial energy metabolism involved in the pathogenesis of depression

重度抑郁症(major depressive disorder,MDD)通常是一种以快感缺失,认知功能减弱以及社交障碍为特征的情感障碍疾病。近年来的研究表明,在慢性应激动物模型以及MDD患者中普遍存在能量代谢紊乱的现象。线粒体在能量代谢中起着核心作用,同时还参与调节氧化应激和细胞凋亡的过程。那么,线粒体代谢异常改变可能与抑郁症的发生存在一定的联系。现对线粒体能量代谢参与抑郁症发病的研究进展进行综述,为抑郁症发病机制以及靶向线粒体为基础的新型治疗策略的研究提供参考。

Major depressive disorder(MDD)is usually an affective disorder characterized by anhedonia,cognitive decline,and social disorders.In recent years,some studies have shown that energy metabolism disorder is widespread in chronic stress models and MDD patients.Mitochondria play a central role in energy metabolism and are also involved in the regulation of oxidative stress and cell apoptosis.Thus,the abnormal changes in mitochondrial metabolism may be related to the occurrence of depression.This review summarizes the research progress of mitochondrial energy metabolism involved in the pathogenesis of depression,so as to provide reference for the research of the pathogenesis of depression and new treatment strategies based on mitochondria.