25-羟维生素D与老年高血压患者睡眠质量的关系

Correlation between 25-hydroxyvitamin D and Sleep Quality in Elderly Patients with Hypertension

目的:探讨老年高血压患者睡眠质量与25-羟维生素D[25(OH)D]之间的关系。方法:收集221例老年高血压患者的睡眠情况和一般资料。运用匹兹堡睡眠质量指数量表(PSQI)评估老年高血压患者的睡眠质量,依据PSQI评分将受试者分成睡眠正常组(N1组,n=73)和睡眠障碍组(N2组,n=148);运用Spearman相关分析评价一般资料及睡眠质量与25(OH)D的相关性;老年高血压患者25(OH)D的多因素间的相关性应用logistic回归分析。结果:两组性别、体育锻炼状况、吸烟状况、饮酒状况、TG、TC、HDL-C比较,差异均无统计学意义(P>0.05);两组年龄、BMI、25(OH)D、LDL-C、Hcy比较,差异均有统计学意义(P<0.05)。年龄、BMI、LDL-C、Hcy与睡眠质量呈负相关(r_(s)=-0.161、-0.215、-0.216、-0.293,P<0.05),25(OH)D与睡眠质量呈正相关(r_(s)=0.303,P<0.05)。高BMI值、高LDL-C及Hcy均是老年高血压患者睡眠障碍的独立危险因素,高25(OH)D是老年高血压患者睡眠障碍的保护因素。结论:老年高血压患者体内25(OH)D普遍偏低,且25(OH)D与老年高血压患者的睡眠质量有关,25(OH)D越高,睡眠质量越好。适量的维生素D可能对老年高血压患者的睡眠状况有改善作用,降低睡眠障碍的发生率,促进老年高血压患者晚年生活品质的提升。

Objective:To explore the relation between sleep quality and serum 25-hydroxyvitamin D[25(OH)D]in elderly patients with hypertension.Method:The sleep and general data of 221 elderly patients with hypertension were collected,Pittsburgh sleep quality index(PSQI)was used to assess sleep quality of elderly patients with hypertension.The subjects were divided into normal sleep group(N1 group,n=73)and sleep disorder group(N2 group,n=148)according to PSQI score.Spearman correlation analysis was used to evaluate the correlation between general information,sleep quality and 25(OH)D.logistic regression was used to analyze the correlation of multiple factors affecting sleep quality in elderly patients with hypertension.Result:There were no significant differences in gender,physical exercise status,smoking status,drinking status,TG,TC and HDL-C between two groups(P>0.05).There were statistically significant differences in age,BMI,25(OH)D,LDL-C and Hcy between two groups(P<0.05).Age,BMI,LDL-C and Hcy were negatively correlated with sleep quality(r_(s)=-0.161,-0.215,-0.216,-0.293,P<0.05),while 25(OH)D was positively correlated with sleep quality(r_(s)=0.303,P<0.05).High BMI,high LDL-C and high Hcy were independent risk factors for sleep disturbance in elderly patients with hypertension,high 25(OH)D was a protective factor of sleep disorder in elderly patients with hypertension.Conclusion:Serum 25(OH)D level in elderly patients with hypertension is generally lower.The sleep quality of elderly patients with hypertension is closely related to the serum 25(OH)D level.The higher serum 25(OH)D level,the better the sleep quality.Proper amount of vitamin D may improve the sleep status of elderly patients with hypertension,reduce the incidence of sleep disorders and enhance their quality of life.