腹腔镜卵巢囊肿剥除术对患者机体创伤应激及卵巢储备的影响研究

Study on the Influence of Laparoscopic Ovarian Cyst Dissection for Body Traumatic Stress and Ovarian Reserve of Patients

目的:探究与观察腹腔镜卵巢囊肿剥除术对患者机体创伤应激及卵巢储备的影响。方法:选取2018年10月-2020年6月100例拟行卵巢囊肿手术患者,根据随机数字表法将其分为对照组和观察组,每组50例。对照组采用开腹卵巢囊肿剥除术,观察组采用腹腔镜卵巢囊肿剥除术。比较两组不良反应发生情况,比较两组术前及术后1、3、5 d的应激激素(Cor、AngⅡ、ALD)及炎性应激指标(TNF-α、IL-1β、IL-6),比较两组术后1、3个月的卵巢储备指标(AMH、INHB、窦状卵泡数)。结果:术前,两组Cor、AngⅡ、ALD、TNF-α、IL-1β、IL-6比较,差异均无统计学意义(P>0.05);术后1、3、5 d,观察组Cor、AngⅡ、ALD、TNF-α、IL-1β、IL-6均低于对照组,差异均有统计学意义(P<0.05)。术前,两组AMH、INHB、窦状卵泡数比较,差异均无统计学意义(P>0.05);术后1、3个月,观察组AMH、INHB、窦状卵泡数均高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜卵巢囊肿剥除术可更有效地控制患者的机体创伤应激,对卵巢储备的不良影响也相对较小,在卵巢囊肿患者中的应用价值较高。

Objective:To investigate and observe the influence of laparoscopic ovarian cyst dissection for body traumatic stress and ovarian reserve of patients.Method:A total of 100 laparoscopic ovarian cyst dissection from October 2018 to June 2020 were selected,and they were divided into control group and observation group according to the random number table,50 cases in each group.The control group was treated with open ovarian cyst dissection,and the observation group was treated with laparoscopic ovarian cyst dissection.The incidence of adverse reactions was compared between the two groups.The stress hormones(Cor,AngⅡ,ALD)and inflammatory stress indexes(TNF-α,IL-1β,IL-6)before surgery and 1,3,5 d after surgery were compared between two groups,and the ovarian reserve indexes(AMH,INHB,number of sinus follicles)1,3 months after surgery were compared between two groups.Result:Before surgery,there were no significant differences in Cor,AngⅡ,ALD,TNF-α,IL-1β,IL-6 between two groups(P>0.05);1,3 and 5 d after surgery,Cor,AngⅡ,ALD,TNF-α,IL-1β and IL-6 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before surgery,there were no significant differences in AMH,INHB and the number of sinus follicles between two groups(P>0.05);1 and 3 months after surgery,AMH,INHB and the number of sinus follicles in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:The laparoscopic ovarian cyst dissection can more effectively control the body traumatic stress of patients,and bad influence for the ovarian reserve is relatively smaller,so its application value in the patients with ovarian cyst is higher.