纳洛酮联合胞磷胆碱治疗脑梗死效果的Meta分析

Naloxone Combined with Citicoline in the Treatment of Cerebral Infarction:a Meta-analysis

目的:系统评价纳洛酮联合胞磷胆碱治疗脑梗死的效果及安全性。方法:全面检索PubMed、Cochrane Library、Embase、SinoMed、知网、万方及维普医药在线数据库创库至2020年12月3日关于纳洛酮联合胞磷胆碱治疗脑梗死的随机对照试验(RCT),并追溯所纳入研究的参考文献,由两位研究人员根据纳入与排除标准各自对全部研究进行筛选与评价,然后提取数据,达成共识后运用RevMan 5.4软件统计分析。结果:纳入17篇文献,共1359例患者,经Meta分析表明:联合治疗组脑梗死疗效优于常规治疗组[OR=6.04,95%CI(2.66,13.71),P<0.0001],亦优于胞磷胆碱组[OR=5.31,95%CI(3.71,7.61),P<0.00001]。各组均未发生严重不良反应。结论:纳洛酮联合胞磷胆碱治疗脑梗死效果显著,安全性较好。

Objective:To review systematically the curative effect and safety of Naloxone combined with Citicoline in the treatment of cerebral infarction.Method:The databases of PubMed,Cochrane Library,Embase,SinoMed,CNKI,WanFang and VIP medicine were retrieved for collecting randomized controlled trials about Naloxone combined with Citicoline in the treatment of cerebral infarction before December 3,2020,and reference lists were also searched.According to the inclusion and exclusion criteria,two reviewers screened and assessed independently the potential studies,and then the data was extracted,the data was given a Meta-analysis by using RevMan 5.4 software after consensus.Result:A total of 17 literatures were included,involving 1359 patients.Meta-analysis showed:the clinical curative effect of the combination group in treating cerebral infarction was better than those of routine treatment group[OR=6.04,95%CI(2.66,13.71),P<0.0001]and Citicoline group[OR=5.31,95%CI(3.71,7.61),P<0.00001].There were no serious adverse reactions in each groups.Conclusion:Naloxone combined with Citicoline in the treatment of cerebral infarction has significant curative effect,and the safety is good.