自拟黄疸汤外洗联合蓝光治疗新生儿高胆红素血症的效果及安全性

Efficacy and Safety of External Washing with Self-made Huangdan Decoction Combined with Blue Light in the Treatment of Neonatal Hyperbilirubinemia

目的:探究自拟黄疸汤外洗联合蓝光治疗新生儿高胆红素血症的效果及安全性。方法:选择2019年4月-2020年4月本院收治的高胆红素血症新生儿400例为研究对象。根据随机抽签原则将患儿分为对照组和研究组,每组200例。对照组采用蓝光治疗,研究组在对照组基础上联用自拟黄疸汤外洗。观察两组临床疗效,比较两组治疗前后血清总胆红素水平及治疗期间不良反应发生情况。结果:研究组的临床总有效率为98.00%,高于对照组的92.50%,差异有统计学意义(P<0.05)。治疗前1 d,两组的血清总胆红素水平比较,差异无统计学意义(P>0.05);治疗7 d后,两组的血清总胆红素水平均低于治疗前1 d,且研究组低于对照组,差异均有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对高胆红素血症新生儿采用自拟黄疸汤外洗联合蓝光治疗,可提高临床疗效,显著降低患儿血清总胆红素水平,且安全性较高。

Objective:To explore the effect and safety of external washing with self-made Huangdan Decoction combined with blue light in the treatment of neonatal hyperbilirubinemia.Method:A total of 400 neonates with hyperbilirubinemia admitted to our hospital from April 2019 to April 2020 were selected as the study subjects.According to the principle of random drawing,the patients were divided into control group and study group,200 cases in each group.The control group was treated with blue light,the study group was combined with external washing of self-made Huangdan Decoction on the basis of the control group.The clinical effects of the two groups were observed,serum total bilirubin levels before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Result:The total clinical effective rate of the study group was 98.00%,higher than 92.50%of the control group,the difference was statistically significant(P<0.05).1 d before treatment,comparison of serum total bilirubin levels between the two groups,there was no significant difference(P>0.05);after 7 d of treatment,serum total bilirubin level in two groups were lower than those at 1 d before treatment,and the study group was lower than that of the control group,the differences were statistically significant(P<0.05).Comparison of the incidence of adverse reactions between the two groups during treatment,there was no significant difference(P>0.05).Conclusion:External washing of self-made Huangdan Decoction combined with blue light can improve the clinical efficacy and significantly reduce the level of serum total bilirubin in neonates with hyperbilirubinemia,the safety is high.