参附滴丸的成型工艺研究

Study on the forming technology of ginseng and aconite dropping pill

目的优选参附滴丸的最佳成型工艺。方法选取基质的种类(A)、参附提取物与基质的配比(B)、溶药箱的温度(C)、冷却剂的温度(D)四个主要影响因素进行正交试验,以滴丸的质量变异系数、圆整度、溶散时限作为评价指标进行评价。结果参附提取物与聚乙二醇4000按照1:1的比例在80℃条件下熔融,在温度为15℃的冷却箱中冷凝形成的参附滴丸成型效果较好。结论该工艺可用于优化参附滴丸的生产。

Objective To optimize the best forming process of shenfu dropping pills.Methods The orthogonal test was carried out by selecting four key factors: the type of matrix(A),the ratio of Shenfu extract to matrix(B),the temperature of dissolution chamber(C) and the temperature of dispenser(D).The quality variation coefficient, roundness and dissolution time of dropping pills were taken as evaluation indexes.Results Ginseng extract and polyethylene glycol 4000 were melted at 80 ℃ in 1:1 ratio, and condensation formed the dropping pills in a cooling box at 15 ℃.Conclusion The experimental results can improve the production process of shenfu dropping pills.