延续性护理对乳腺癌术后患者生活质量影响的Meta分析

Meta-analysis of the effect of continuous nursing on the quality of life of patients with breast cancer after operation

目的通过Meta分析评价延续性护理对乳腺癌患者术后生活质量的影响。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、Pubmed、Cochrane Library、Web of Science数据库,收集延续性护理对乳腺癌术后患者生活质量影响的随机对照研究,检索时间从建库至2020年7月17日。由2名研究者采用采用Cochrane手册5.1版偏倚风险评估工具进行文献质量评价并提取资料。采用RevMan 5.3软件进行Meta分析。结果共纳入14项随机对照试验研究,共1296例患者。延续性护理干预能够显著提高乳腺癌术后患者的生活质量[MD=10.08,95%CI(8.56,11.60),P<0.001],缓解患者术后焦虑[MD=-8.94,95%CI(-10.12,-7.77),P<0.001]和抑郁状况[MD=-8.05,95%CI(-10.17,-5.94),P<0.001]以及提高患者术后依从率[RR=1.21,95%CI(1.06,1.37),P=0.004]。结论延续性护理在提高乳腺癌患者术后生活质量和依从性,以及改善负面情绪方面具有一定意义。但所纳入文献数量有限且质量不高,今后需纳入高质量、多中心的随机对照研究来进一步论证。

Objective To evaluate the effect of continuous nursing on postoperative quality of life of breast cancer patients through meta-analysis.Methods CNKI,Wanfang, VIP,CBM,Pubmed, Cochrane Library, Web of Science databases were used to collect randomized controlled studies on the effect of continuous nursing on the quality of life of breast cancer patients after operation.The retrieval time was from the establishment of the database to July 17,2020.Results 14 randomized controlled trials involving 1296 patients were included.Continuous nursing intervention could significantly improve the quality of life of breast cancer patients [MD=10.08,95%CI(8.56,11.60),P<0.001],relieve postoperative anxiety [MD=-8.94,95%CI(-10.12,-7.77),P<0.001] and depression [MD=-8.05,95%CI(-10.17,-5.94),P<0.001],and improve postoperative compliance [RR=1.21,95%CI(1.06,1.37),P=0.004].Conclusion Continuous nursing is of great significance in improving the quality of life and compliance of breast cancer patients after operation, as well as improving the negative emotions.However, the number and quality of the included literatures are limited, so it is necessary to include high-quality, multicenter randomized controlled studies to further demonstrate.