涎腺癌患者应用局部扩大切除手术的治疗效果及其对血清TSGF表达水平的影响

Effect of Local Extended Resection in Patients with Salivary Gland Carcinoma and Its Influence on Serum TSGF Expression Level

目的:探讨局部扩大切除手术在涎腺癌患者中的临床效果及对血清TSGF表达水平的影响。方法:选择2017年5月-2019年10月涎腺癌患者94例,按随机数字表法将患者分为对照组与观察组,各47例。对照组采用放化疗治疗,观察组采用局部扩大切除术治疗。比较两组近期疗效。两组治疗后均进行1年随访,比较两组治疗前及治疗后1年肿瘤特异性生长因子(TSGF)、癌胚抗原(CEA)、肿瘤相关抗原(CA50)及治疗后1、6、12个月死亡率。结果:观察组治疗有效率为74.47%,高于对照组的53.19%(P<0.05)。观察组治疗后1年TSGF、CEA及CA50均低于对照组(P<0.05)。观察组治疗后6、12个月死亡率均低于对照组(P<0.05)。结论:将局部扩大切除手术用于涎腺癌患者中能获得较高的近期疗效,能改善肿瘤标志物水平,有助于降低死亡率,值得推广应用。

Objective:To investigate the clinical effect of local extended resection in patients with salivary gland carcinoma and its influence on the expression of serum TSGF.Method:A total of 94 patients with salivary gland carcinoma from May 2017 to October 2019 were selected,and the patients were divided into control group and observation group according to the random number table method,with 47 cases in each group.The control group was treated with radiotherapy and chemotherapy,and the observation group was treated with local enlarged resection.The short-term efficacy was compared between the two groups.The two groups were followed up for 1 year after treatment,and tumor specific growth factor(TSGF),carcinoembryonic antigen(CEA),tumor associated antigen(CA50)and 1,6 and 12 months after treatment mortality rates were compared between the two groups.Result:The effective rate in observation group was 74.47%,which was higher than 53.19%in control group(P<0.05).TSGF,CEA and CA50 in observation group were lower than those in control group at 1 year after treatment(P<0.05).The 6 and 12 months after treatment mortality rates of observation group were lower than those of control group(P<0.05).Conclusion:The local extended resection can obtain high short-term curative effect in patients with salivary gland cancer,improve the level of tumor markers,and help reduce mortality.It is worthy of popularization and application.