血清可溶性gp130和IL-6R水平与ST段抬高型心肌梗死患者心肌坏死的相关性

Correlation between Serum Soluble gp130 and IL-6R Levels and Myocardial Necrosis in Patients with ST-segment Elevation Myocardial Infarction

目的:探讨血清可溶性糖蛋白链细胞因子亚单位130通路(gp130)和白细胞介素-6受体(IL-6R)水平与ST段抬高型心肌梗死(STEMI)患者心肌坏死的相关性。方法:回顾性分析2017年10月-2020年10月本院收治的85例STEMI患者的临床资料,依照冠状动脉病变情况将患者分为单支病变组(n=38)、双支病变组(n=26)和三支病变组(n=21)。对比三组血清可溶性gp130、IL-6R和IL-6水平情况并分析其与患者心肌坏死情况的相关性,根据住院期间和3年随访期间存活情况将患者分为死亡组(n=11)和存活组(n=74),对比两组各指标情况,并分析可溶性gp130、IL-6R和IL-6水平对STEMI患者预后的预测价值。结果:三组血清可溶性gp130、IL-6R和IL-6水平对比,差异均有统计学意义(P<0.05),三支病变组高于双支病变组高于单支病变组。Spearman相关分析结果显示:血清可溶性gp130、IL-6R和IL-6水平与STEMI患者心肌坏死情况均呈正相关(P<0.05)。生存组与死亡组性别对比,差异无统计学意义(P>0.05);生存组与死亡组年龄、入院心率、gp130、IL-6R和IL-6对比,差异均有统计学意义(P<0.05);logistic回归分析结果显示:gp130、IL-6R和IL-6均为STEMI患者预后的影响因素(P<0.05)。结论:STEMI患者心肌坏死情况与gp130和IL-6R水平关系密切,且对STEMI患者预后情况可能具有预测价值。

Objective:To investigate the correlation between serum soluble glycoprotein chain cytokine subunit 130 pathway(gp130)and interleukin-6 receptor(IL-6R)levels and myocardial necrosis in patients with ST-segment elevation myocardial infarction(STEMI).Method:The clinical data of 85 patients with STEMI treated in our hospital from October 2017 to October 2020 were retrospectively analyzed,the patients were divided into single vessel disease group(n=38),double vessel disease group(n=26)and three vessel disease group(n=21)according to the coronary artery disease.The levels of serum soluble gp130,IL-6R and IL-6 were compared among three groups and their correlation with myocardial necrosis in patients with STEMI was analyzed.The patients who died during hospitalization and 3-year follow-up were divided into death group(n=11)and survival group(n=74),the indexes of two groups were compared,and the predictive value of soluble gp130,IL-6R and IL-6 levels in prognosis of patients with STEMI was analyzed.Result:The levels of serum soluble gp130,IL-6R and IL-6 were significantly different among three groups(P<0.05),and the levels of soluble gp130,IL-6R and IL-6 in three vessel disease group were higher than those in double vessel disease group and single vessel disease group.Spearman correlation analysis showed that serum soluble gp130,IL-6R and IL-6 levels were positively correlated with myocardial necrosis in patients with STEMI(P<0.05).there was no significant difference in gender between survival group and death group(P>0.05);there were significant differences in age,admission heart rate,gp130,IL-6R and IL-6 levels between survival group and death group(P<0.05);logistic regression analysis showed that gp130,IL-6R and IL-6 were prognostic factors of patients with STEMI(P<0.05).Conclusion:Myocardial necrosis in patients with STEMI is closely related to the levels of gp130 and IL-6R,and may have predictive value for the prognosis of patients with STEMI.