单纯性汗腺棘皮瘤的临床病理分析

Clinical and pathological analysis of hidroacanthoma simplex

为总结单纯性汗腺棘皮瘤(hidroacanthoma simplex,HS)的临床及组织病理特点,回顾性分析我院2015年1月至2020年8月诊治的5例HS患者及CNKI中检索文献报道的16例HS患者资料。结果示21例患者平均年龄61.1岁(36~86岁),其中男8例,女13例,病程5个月至50年,皮损主要见于躯干、下肢(17/21),也可见于上肢(4/21),皮损表现为斑块,无自觉症状。组织病理表现为表皮内境界清楚的肿瘤细胞团块,肿瘤细胞呈立方形或卵圆形,部分细胞胞质内含有糖原,呈透明状,局部可见导管分化,真皮内无明显变化。免疫组化染色显示:EMA阳性,CEA在导管分化处阳性。16例患者行手术切除,随访无复发及恶变,5例患者具体治疗方式不详。

To investigate the clinical and histopathological features of,hidroacanthoma simplex(HS),the data of 5 patients with HS diagnosed from January 2015 to August 2020 in our hospital and 16 patients with HS in reported studies searched in CNKI were analyzed.Results showed the age at onset ranged from 36 to 86 years with the mean of 61.1 years.Of 21 patients,13 were female,8 were male,and the course of the disease ranged from 5 months to 50 years.The lesions mainly located on lower extremities and the trunk.Skin biopsy features were the“Jadassohn phenomenon”composed of bland basaloid cells that were smaller than neighboring epidermal keratinocytes,and intracytoplasmic glycogen and occasional ductal structures within the nests of cells were also found.Immunohistochemical examination showed the cytoplasm of some tumor cellsa positive for EMA and the normal ductal structure positive for CEA.Sixteen patients were received resection with no recurrence and malignant transformation in follow-up,and the treatment is unknown in 5 patients.