HIF-1α与VEGF在中耳胆脂瘤中的研究进展

Advancements of HIF-1αand VEGF in middle ear cholesteatoma

中耳胆脂瘤是一种主要由角蛋白碎片和角化鳞状上皮及其周围的结缔组织组成的具有侵袭性的疾病,受很多因素影响,发病机制不明确。随着科学技术的进步,研究学者开始从分子生物学方面研究中耳胆脂瘤的发病机制,其中缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子(VEGF)具有多种生物学功能,在中耳胆脂瘤的发病机制中可能有着重要作用。本文主要综述HIF-1α和VEGF的生物学特性,以及两者在中耳胆脂瘤的增殖、凋亡、免疫反应及侵蚀性生长等方面可能的作用,从而为了解HIF-1α和VEGF在胆脂瘤的发病机制中的作用和中耳胆脂瘤的非手术治疗、药物研发提供可能。

Cholesteatoma of the middle ear is an aggressive disease mainly composed of keratin fragments,keratinized squamous epithelium and its surrounding connective tissue.It is influenced by many factors and its pathogenesis is unclear.With the progress of science and technology,researchers began to study the pathogenesis of middle ear cholesteatoma from the aspect of molecular biology.hypoxia-inducible factor 1 alpha(HIF-1α)and vascular endothelial growth factor(VEGF)have a variety of biological functions,they may play important roles in the middle ear cholesteatoma.In this review,we summarized the biological characteristics of HIF-1αand VEGF,and their possible roles in proliferation,apoptosis,immune response and aggressive growth of middle ear cholesteatoma,so as to provide the possibility for understanding the role of HIF-1αand VEGF in the pathogenesis of cholesteatoma and the non-surgical treatment and drug development of middle ear cholesteatoma.