低负荷与高负荷剂量氯吡格雷用于急性ST段抬高型心肌梗死的近远期疗效比较

Comparison of short-term and long-term efficacy of low load and high load dose clopidogrel on acute ST-segment elevation myocardial infarction

目的比较低负荷与高负荷剂量氯吡格雷用于急性ST段抬高型心肌梗死的近远期疗效。方法纳入2019年1月至2019年12月本院收治的86例急性ST段抬高型心肌梗死患者,按照随机数字表法将其分为对照组(43例,给予低负荷剂量氯吡格雷治疗)和观察组(43例,给予高负荷剂量氯吡格雷)。比较两组治疗效果。结果治疗后,两组的血小板最大聚集率降低,一氧化氮水平升高,左室射血分数增大,左房内径、左室舒张末期内径、左室收缩末期内径均缩小,且观察组优于对照组(P<0.05)。观察组的近期治疗总有效率高于对照组,远期不良事件总发生率低于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论高负荷剂量氯吡格雷应用于急性ST段抬高型心肌梗死治疗的近远期疗效均高于低负荷剂量氯吡格雷,且用药安全性可靠。

Objective To compare the short-term and long-term efficacy of low load and high load dose clopidogrel on acute ST-segment elevation myocardial infarction.Methods A total of 86 patients with acute ST-segment elevation myocardial infarction treated in our hospital from January 2019 to December 2019 were enrolled and divided into control group(43 cases,treated with low load dose clopidogrel)and observation group(43 cases,treated with high load dose clopidogrel)according to random number table method.The therapeutic effects of the two groups were compared.Results After treatment,the maximum platelet aggregation rate decreased,nitric oxide level increased,the left ventricular ejection fraction increased,and the left atrial diameter,left ventricular end diastolic diameter and left ventricular end systolic diameter decreased in the two groups,and those in the observation group were better than the control group(P<0.05).The total effective rate of recent treatment in the observation group was higher than that in the control group,and the total incidence of long-term adverse events was lower than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The short-term and long-term efficacy of high load dose clopidogrel in the treatment of acute ST-segment elevation myocardial infarction are higher than those of low load dose clopidogrel,and the drug safety is reliable.