Sprouty在人晶状体上皮细胞上皮间质转化中的作用机制

Mechanism of Sprouty in epithelial mesenchymal transformation of human lens epithelial cells

Sprouty蛋白是受体酪氨酸激酶(RTK)等信号通路的负调节分子,近年来的研究结果表明,抑制Sprouty蛋白家族的表达后可引起人晶状体上皮细胞的上皮间质转化,最终导致白内障的发生和发展,那么Sprouty蛋白如何参与人晶状体上皮细胞的上皮间质转化,本文就其机制进行综述。

Sprouty protein is a negative regulator of receptor tyrosine kinase(RTK)and other signal pathways.Recent research results show that inhibiting the expression of Sprouty protein family can cause epithelial mesenchymal transformation of human lens epithelial cells,and eventually lead to the occurrence and development of cataract.How does Sprouty protein participate in epithelial mesenchymal transformation of human lens epithelial cells?This paper reviews its mechanism.