远志皂苷治疗脑卒中后认知障碍的研究进展

Research Progress on Polygala Saponins in the Treatment of Cognitive Impairment after Stroke

综述了脑卒中后出现认知功能障碍的发病机制及远志皂苷延缓和抑制脑卒中后认知障碍的研究进展。远志皂苷是中药远志的主要活性成分,可通过抑制大脑内β-淀粉样蛋白(Aβ)聚集、减轻Aβ产生的神经毒性,减少tau蛋白异常磷酸化,消除神经炎症、抑制促炎性细胞因子的释放,以及调节中枢胆碱能系统等途径治疗PSCI。

This paper reviews the pathogenesis of cognitive dysfunction after stroke in recent years and the research progress on polyhige saponin in delaying and inhibiting the post-stroke cognitive impairment.Polygala saponins,the main active ingredient of Yuanzhi(Polygala),can treat post-stroke cognitive impairment according to inhibiting the beta-amyloid(Aβ)gather in the brain,alleviating Aβneurotoxicity,reducing the abnormal tau protein phosphorylation,eliminating nerve inflammation,inhibiting the release of pro-inflammatory cytokines and adjusting the central cholinergic system.