金属有机骨架材料沸石咪唑酯骨架-8在药物递送系统中的研究进展

Advance in research of metal organic framework ZIF-8 in drug delivery system

沸石咪唑酯骨架-8(zeolitic imidazolate framework-8,ZIF-8)是由锌离子和2-甲基咪唑组成的一种金属有机骨架材料,具有易合成、比表面积大、孔隙率高、pH敏感、热稳定性好及生物相容性好等特点,在气体吸附、催化、传感等方面应用广泛。近年来,ZIF-8作为药物载体的研究逐渐增多,在抗肿瘤药物、抗菌药物、降血糖药物等方面均有应用。本文对ZIF-8的合成方法及其在化学药物、天然药物、生物技术药物递送系统中的应用现状进行了综述,分析ZIF-8在不同种类药物递送系统中的优势及应用特点,以期为ZIF-8递送药物的进一步研究提供参考。

Zeolitic imidazolate framework-8(ZIF-8)is a metal organic framework composed of zinc ions and 2-methylimidazole(MIM).It exhibits unique advantages,such as easiness to synthesize,large surface area,high porosity,pH responsiveness,as well as excellent thermal stability and biocompatibility,due to all these properties,it is widely used in gas adsorption,catalysis and sensing.In recent years,research on ZIF-8 as a drug carrier has gradually increased,and it has been applied in anticancer drugs,antibacterial drugs,and hypoglycemic drugs,etc.This review focuses on the recent development of ZIF-8 synthesis methods and its application in chemical drugs,natural drugs,and biotechnology drug delivery systems,and analyzes the advantages and application characteristics of ZIF-8 in different types of drug delivery systems,in order to provide a reference for further research of ZIF-8 to deliver drugs.