基于运动想象的脑机接口技术运用于脑卒中瘫痪患者脑功能激活和神经网络重塑的研究进展

Advances in the application of motor imagery based brain computer interface systems for brain function activation and neural network remodeling in patients with paralysis after stroke

运动想象及基于此开发的脑机接口技术已尝试运用于因脊髓损伤、脑卒中、多发性硬化等神经系统疾病所导致的语言交流及运动障碍患者中,并取得了较好的临床效果。目前的研究结果显示,脑机接口技术可以使脑卒中患者脑功能激活,脑电信号频率增强、持续时间延长且更加稳定;影像学结果表明,脑机接口技术可以使脑卒中患者双侧脑半球间及患侧脑半球内功能连接显著增加。文中就基于运动想象的脑机接口技术对于脑卒中患者脑功能的激活及神经网络的重塑进行综述,归纳总结该技术相关的机制研究进展,为该技术在临床及未来科研中的运用提供借鉴和参考。

Motor imagery(MI)and its related brain computer interface(BCI)technologies have been used for speech and movement disorders in patients with spinal cord injury,stroke,multiple sclerosis,etc.Current studies have shown that BCI can activate brain function in stroke patients with enhanced frequency,longer duration and more stable electroencephalogram signals.Imaging results showed a significant increase in functional connectivity between the two hemispheres and within the affected hemispheres.In this paper,MI-BCI for stroke patients with brain function activation and neural network remodeling were reviewed,the research progress on mechanisms of the technology was summarized,to provide reference for the application of the technology in clinical and future research.