孟德尔随机化及其在眼病研究中的应用进展

Application of Mendelian randomization in ophthalmology and other medical fields

近年来,孟德尔随机化的应用在全球范围内越来越广泛。它以基因作为工具变量,可以排除体系中混杂因素和反向因果的干扰,有效地判断暴露因素与结局的因果关联,对于医学领域的病因探索具有独特优势。本文对国内外孟德尔随机化在眼科和其他医学领域的应用进行综述,为相关性研究和因果研究在眼科的发展提供新思路。

In recent years,the application of Mendelian randomization has become more and more widely in the world.By taking genes as instrumental variables,it can eliminate the interference of confounding factors and reverse causality in the system,and effectively judge the causal correlation between exposure factors and outcomes,which has a unique advantage for etiological exploration in the medical field.This article reviews the application of Mendelian randomization in ophthalmology and provides new ideas for the development of correlational and causal studies in Ophthalmology.