醒脑静注射液联合纳洛酮、维生素C、维生素B_(6)治疗急性酒精中毒30例

Xingnaojing Injection Combined with Naloxone,Vitamin C and Vitamin B_(6) in Treating 30 Cases of Acute Alcoholic Intoxication

目的:探讨醒脑静注射液联合纳洛酮、维生素B_(6)及维生素C治疗急性酒精中毒的临床疗效。方法:将60例急性酒精中毒患者,按照随机数字表法,分为观察组和对照组,每组30例。观察组给予醒脑静注射液联合纳洛酮、维生素B_(6)及维生素C支持治疗;对照组采用纳洛酮、维生素B_(6)及维生素C等常规对症治疗。观察两组临床疗效、临床症状改善情况及症状消失时间。结果:总有效率观察组为96.7%(29/30),对照组为83.3%(25/30),两组比较,差异有统计学意义(P<0.05)。两组患者苏醒后,头晕头痛、恶心呕吐、胸闷心慌发生率比较,差异均有统计学意义(P<0.05)。两组患者意识恢复时间、动作恢复时间及症状消除时间比较,差异有统计学意义(P<0.05)。格拉斯哥昏迷评分、急性生理学及慢性健康状况评分,两组治疗前后组内比较,差异均有统计学意义(P<0.05);治疗后组间比较,差异也有统计学意义(P<0.05)。结论:醒脑静联合纳洛酮、维生素C、维生素B_(6)可以对急性酒精中毒患者起到协同治疗作用,缩短意识恢复时间、动作恢复时间及症状消除时间,预防酒精中毒性脑病可能。

Objective:To explore clinical effects of Xingnaojing injection joined with naloxone,Vitamin C and Vitamin B_(6)in the treatment of acute alcoholic intoxication.Methods:Sixty patients were randomized into the observation group and the control group according to random number table method,30 cases in each group.The observation group was treated by Xingnaojing injection and naloxone,Vitamin C and Vitamin B_(6);and the control group by naloxone,Vitamin C and Vitamin B_(6).To observe clinical effects,the improvements of clinical symptoms and the disappearing time of the symptoms between both groups.Results:Total effective rate of the observation group was 96.7%(29/30),higher than 83.3%(25/30)of the control group,and the difference was statistically significant(P<0.05).After the patients regaining consciousness in two groups,the difference was statistically significant in the incidences of dizziness,headache,nausea and vomiting,chest tightness and palpitation(P<0.05).The difference had statistical meaning in consciousness recovery time,action recovery time and symptom disappearing time between both groups(P<0.05).The difference was statistically significant in Glasgow coma score,the scores of acute physiology and chronic health status within two groups before and after treating(P<0.05);the difference had statistical meaning between both groups after treating(P<0.05).Conclusion:Xingnaojing injection joined with naloxone,Vitamin C and Vitamin B_(6)play a synergistic therapeutic effects in the treatment of acute alcoholic intoxication,shorten consciousness recovery time,action recovery time and symptom disappearing time,and prevent alcoholic encephalopathy.