阻塞性呼吸睡眠暂停综合征与妊娠期糖尿病患者的产后结局及糖代谢的相关性研究

Relationship Between Obstructive Sleep Apnea Syndrome and Postpartum Outcomes and Glucose Metabolism in Women with Gestational Diabetes Mellitus

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并妊娠期糖尿病(GDM)的患者在妊娠结束后OSAHS的转归结局,及不同睡眠障碍表现形式与糖代谢的关系。方法:回顾性分析17例符合OSAHS纳入标准,同时合并GDM的患者产后病历资料,分析其年龄、身体质量指数(BMI)、糖化血红蛋白A1c(HbA1c)等指标,并分3个维度进行比较。结果:1)OSAHS增加GDM转化为糖尿病前期的风险;2)良好的睡眠有利于GDM的远期预后;3)充足的睡眠有利于降低血糖及调控血糖。结论:GDM合并OSAHS的患者,产后OSAHS有所消退,良好的睡眠质量及充足的睡眠时间利于改善GDM患者的糖代谢。

Objective:To investigate the outcomes of OSAHS at the end of pregnancy and the relationship between different manifestations of sleep disorders and glucose metabolism in the patients with obstructive sleep apnea hypopnea syndrome(OSAHS)combined with gestational diabetes mellitus(GDM).Methods:A total of 17 patients with GDM who met OSAHS inclusion criteria were retrospectively analyzed.Age,Body Mass Index(BMI),Hemoglobin A1c(HbA1c)and other indexes were recorded and compared in three dimensions.Results:1)OSAHS increased the risk of GDM conversion to prediabetes;2)Good sleep is beneficial to the long-term prognosis of GDM;3)Adequate sleep is beneficial to reduce blood glucose and regulate blood glucose.Conclusion:In patients with GDM complicated with OSAHS,postpartum OSAHS has subsided.Good sleep quality and sufficient sleep time are beneficial to improve glucose metabolism in patients with GDM.