高脂血症对直肠癌患者围手术期相关指标的影响

The effect of hyperlipidemia on perioperative outcomes of rectal cancer patients

目的探索高脂血症对直肠癌患者围手术期相关指标的影响。方法选择2016年6月至2019年6月在南京江北人民医院普外科接受开腹或腹腔镜直肠癌根治术的86例患者为研究对象,术前行血脂检测,根据检测结果将患者分为高脂血症组(46例)和血脂正常组(40例),比较两组患者手术时间、术中出血量、术后恢复指标、吻合口瘘、切口脂肪液化及切口感染等发生情况,数据采用SPSS21.0进行数据处理。结果高脂血症组的手术时间明显长于正常血脂组,高脂血症组术中出血量高于正常血脂组,差异具有统计学意义;相比于正常血脂组,高脂血症组的术后首次排气、进食、拔除引流管、下床活动和住院时间均延长,差异均具有统计学意义;高脂血症组术后并发症17例(37.0%),正常血脂组为4例(10.0%),高脂血症组高于正常血脂组(χ^(2)=7.027,P=0.008)。结论高脂血症对直肠癌患者手术本身及术后恢复均产生不利影响。

Objective To examine the influence of hyperlipidemia on perioperative outcomes of rectal cancer patients.Methods From June 2016 to June 2019,86 patients who had received laparotomy or laparoscopic radical resection of rectal cancer at the Department of General Surgery of Nanjing Jiangbei People's Hospital were selected as research subjects.Preoperative blood lipids were measured.Based on lipid levels,patients were divided into the hyperlipidemia group(46 cases)and the normal blood lipid group(40 cases).Operative time,intraoperative blood loss,postoperative recovery outcomes,incidence of anastomotic fistula,and incidences of incision fat liquefaction and incision infections were compared between the two groups.SPSS21.0 was used for data analysis.Results Compared with the normal lipid group,the operative time of the hyperlipidemia group was significantly longer and the amount of intraoperative blood loss was higher in the hyperlipidemia group,and the differences were statistically significant.Compared with the normal lipid group,the hyperlipidemia group showed a longer time to first postoperative flatus and to first postoperative oral intake,delayed drainage tube removal and ambulation,and longer hospital stays,with statistically significant differences.There were 17 cases of postoperative complications in the hyperlipidemia group(37.0%)and 4 cases in the normal lipid group(10.0%),and the difference was statistically significant(χ^(2)=7.027,P=0.008).Conclusions Hyperlipidemia has adverse effects on surgical outcomes and postoperative recovery for rectal cancer patients.