油樟叶化学成分及其抗氧化活性研究

Study on Chemical Constituents of Cinnamomum Longepaniculatum and their Antioxidant Activities

采用硅胶、聚酰胺柱层析及重结晶等方法对油樟叶进行提取分离纯化,并结合MS和NMR等波谱技术对其进行测定。结果表明:从油樟叶中分离鉴定得到6个化合物,包括2个为倍半萜类化合物,2个为糖苷类化合物,1个为二氢黄酮醇类及1个为甾醇体类化合物,分别为ar-turmerone(Ⅰ),3S-(+)-9-氧代橙花叔醇(Ⅱ),槲皮素-3-Ο-B-D-葡萄糖苷(Ⅲ),二氢山萘酚(Ⅳ),桷皮素-3-Ο-α-L-鼠李糖苷(Ⅴ),胡萝卜苷(Ⅵ),其中化合物(Ⅰ)、(Ⅳ)和(Ⅵ)均为首次从该植物叶中获得。通过对所分离到的化合物进行抗氧活性研究,发现化合物(Ⅲ)清除DPPH自由基能力比其它五种化合物更强。

Tthe constituents were isolated by column chromatography on silicagel,polyamide and recrystallization.Their structures were determined by MS and NMR spectroscopy.The results show that:6 compounds included 2 terpenes,2 glycosides,1 dihydroflavonols and 1 sterols were obtained.They are ar-turmerone(Ⅰ),3 S-(+)9-Oxonerolidol(Ⅱ),Quercetin-3-O-B-D-glucoside(Ⅲ),dihydronaphthol(Ⅳ),quercetin-3-O-α-L-rhaMnopyran oside(Ⅴ),Daucosterol(Ⅵ).Conclusion:(Ⅰ),(Ⅳ)and(Ⅵ)Compounds were isolated from Cinamomum longepaniculatum leaves for the first time.By studying the antioxidant activity of the compounds isolated from Cinamomum longepaniculatum leaves,Compound(Ⅲ)had stronger DPPH radical scavenging ability than the other five compounds.