Tourette综合征神经影像学研究进展

Advances in imaging studies on neural mechanism of Tourette's syndrome

Tourette综合征(Tourette syndrome,TS)是一种起病于儿童和青少年期的神经发育障碍性疾病,其病理生理学机制尚不完全清楚。近年来影像学研究初步证实,TS的发病机制与皮质-纹状体-丘脑-皮质(cortico-striato-thalamo-cortical,CSTC)回路有关。正电子发射体层成像(positron emission tomography,PET)、功能性磁共振成像(functional magnetic resonance imaging,fMRI)、功能性近红外光谱(functional near-infrared spectroscopy,fNIRS)等功能神经影像方法的应用,为进一步阐明TS的神经病理生理学机制提供了证据。该文分别从神经结构与功能影像学角度,对TS患者CSTC回路各部分结构及功能的改变进行了综述。

Tourette syndrome(TS)is a kind of neurodevelopmental disorder in children and adolescents.Its pathophysiology is still unclear.In recent years,imaging research has gradually pointed to the cortico-striato-thalamo-cortical(CSTC)circuit.The applications of positron emission tomography(PET),functional magnetic resonance imaging(fMRI),and functional near-infrared spectroscopy(fNIRS)provide an objective basis for elucidating the neurophysiological mechanism of TS.This article reviews the changes of CSTC circuit in TS patients from the perspective of structure and functional neuroimaging.