己酮可可碱对非痴呆型脑小血管病患者神经和认知功能障碍的改善作用

Effect of pentoxifylline on neurological and cognitive dysfunction in patients with nondementia cerebral small vessel disease

【目的】基于脑血流量探讨己酮可可碱对非痴呆型脑小血管病(CSVD)患者神经和认知功能障碍的改善作用。【方法】前瞻性选择2019年6月至2020年8月于我院住院的CSVD患者55例作为研究对象,以随机数字表法将其分为对照组(27例)和观察组(28例)。对照组给予常规治疗;观察组在常规治疗的基础上给予己酮可可碱缓释片治疗,对比两组患者治疗前后的神经功能缺损程度(NFDS)、日常生活活动能力(ADL)评分、局部脑血流(rCBF)评分、认知功能评分以及不良反应情况。【结果】治疗后,观察组的NFDS评分显著低于对照组(P<0.05),两组的ADL评分均有所改善,且观察组显著高于对照组(P<0.05);观察组的rCBF评分显著高于对照组(P<0.05),观察组的蒙特利尔认知评估量表(MoCA)评分显著高于对照组(P<0.05),观察组不良反应发生率(3.57%)较对照组(22.21%)低(P<0.05)。【结论】与常规治疗相比,采用己酮可可碱治疗CSVD患者效果更为显著,能改善患者认知功能和神经功能损伤情况,安全性高。

【Objective】To investigate the effect of pentoxifylline on neurological and cognitive dysfunction in patients with nondementia cerebral small vessel disease(CSVD)based on cerebral blood flow.【Methods】A total of 55 patients with cerebrovascular disease who were treated in our hospital from June 2019 to August 2020 were prospectively selected as the research objects,and they were divided into control group(27 cases)and observation group(28 cases)by a numerical table method.The control group was given conventional treatment;the observation group was treated with pentoxifylline sustained-release tablets on the basis of conventional treatment.The neurological functional deficit scale(NFDS),activities of daily living(ADL),regional cerebral blood flow(rCBF),cognitive function and adverse reactions were compared between the two groups.【Results】After treatment,the NFDS score of the observation group was significantly lower than that of the control group(P<0.05);The ADL score of the two groups was improved,and the observation group was significantly higher than that of the control group(P<0.05);the rCBF score of the observation group was significantly higher than that of the control group(P<0.05),the Montreal Cognitive Assessment(MoCA)score of the observation group was significantly higher than that of the control group(P<0.05),and the incidence of adverse reactions in the observation group(3.57%)was lower than that in the control group(22.21%)(P<0.05).【Conclusion】Compared with conventional treatment,pentoxifylline is more effective in the treatment of CSVD patients,which can improve the cognitive and neurological impairment of patients,with higher safety.