新诊断老年2型糖尿病性视网膜病变相关危险因素研究

Analysis of the risk factors of newly diagnosed type 2 diabetic retinopathy in the elderly

目的探讨新诊断老年2型糖尿病性视网膜病变相关危险因素。方法本研究共纳入287例新诊断的老年2型糖尿病患者,根据有无糖尿病性视网膜病变(DR)分为无糖尿病性视网膜病变组(NDR组)和糖尿病性视网膜病变组(DR组),收集两组一般资料、相关血液学指标及并发症情况,通过单因素分析和多因素Logistic回归分析新诊断老年2型糖尿病性视网膜病变的相关危险因素。结果与NDR组相比,糖尿病性视网膜病变组吸烟史比例较大(P=0.013),有更高的HbA1c(P=0.000)、FPG值(P=0.000)、感觉阈值测定值(P=0.021)、相对更低的ABI(P=0.000),即吸烟史、HbA1c、FPG、感觉阈值测定值、ABI有统计学意义(P<0.05)。将单因素分析中有统计学意义的相关指标,包括吸烟史、HbA1c、FPG、感觉阈值测定值、ABI纳入多因素Logistic分析模型中,结果显示吸烟史、HbA1c、FPG、降低的ABI有统计学意义(P<0.05)。即新诊断老年2型糖尿病性视网膜病变与吸烟史(OR=1.317,95%CI 1.108~1.315,P=0.024),HbA1c(OR=1.605,95%CI 1.196~2.154,P=0.002),FPG(OR=1.242,95%CI 1.085~1.421,P=0.002),低ABI(OR=0.405,95%CI 0.471~0.826,P=0.000)风险增加相关。结论吸烟史、HbA1c、FPG、低ABI可能作为新诊断老年2型糖尿病视网膜病变的独立危险因素来预测其发生发展。

Objective To explore the newly diagnosed elderly type 2 diabetic retinopathy related risk factors.Methods A total of 287 newly diagnosed elderly patients with type 2 diabetes were included.Based on the presence or absence of diabetic retinopathy,the patients were divided into non-diabetic retinopathy group(NDR group)and diabetic retinopathy group(DR group).Collect general conditions,relevant hematology indicators and complications.Analyze the risk factors of newly diagnosed elderly type 2 diabetic retinopathy by univariate analysis and multivariate logistic regression.Results Compared with the NDR group,the DR group had a higher percentage of smoking history(P=0.013),higher HbA1c(P=0.000),FPG value(P=0.000)and sensory threshold measurement value(P=0.021),and the lower ABI(P=0.000).That is,smoking history,HbA1c,FPG,sensory threshold measurement value,ABI were considered statistically significant(P<0.05).In the multivariate logistic regression analysis,the results showed that newly diagnosed elderly type 2 diabetic retinopathy was associated with an increased risk of the smoking history(OR=1.317,95%CI 1.108~1.315,P=0.024),HbA1c(OR=1.605,95%CI 1.196~2.154,P=0.002),FPG(OR=1.242,95%CI 1.085~1.421,P=0.002),low ABI(OR=0.405,95%CI 0.471~0.826,P=0.000).Conclusion Smoking history,HbA1c,FPG,and low ABI may be used as independent risk factors for newly diagnosed elderly type 2 diabetic retinopathy to predict its occurrence and development.