老年脑血管病患者非快速眼动睡眠期睡眠障碍对认知功能的影响及相关性分析

The effect of non-rapid eye movement sleep disorder on cognitive function in senile cerebrovascular disease and its correlation analysis

目的分析脑血管病患者非快速眼动睡眠期睡眠障碍对认知功能的影响及其相关性。方法回顾性分析2018年12月至2020年12月在本院接受治疗的120例脑血管病患者的临床治疗,根据睡眠障碍情况分组。对照组(n=60)为不伴非快速眼动睡眠期睡眠障碍患者,观察组(n=60)为伴非快速眼动睡眠期睡眠障碍患者。对比、分析两组患者的多导睡眠指标和认知功能(MOCA)评分。结果与对照组相比,观察组患者的执行功能、记忆力、注意力、定向力、语言流畅性及MoCA总分明显更低;与对照组比较观察组SOL、NREM S1期睡眠时间更长,WUT更多;SE、NREM S2期睡眠时间、NREM S3+S4期睡眠时间及TST更少(P<0.05)。Spearman相关分析结果显示,观察组患者MOCA总分、注意力与MREM S3+S4期睡眠总时间呈正相关,记忆力与MREM S3+S4期睡眠总时间呈负相关,执行功能、定向力与MREM S2期睡眠时间呈正相关(P<0.05)。结论非快速眼动睡眠期睡眠障碍会导致脑血管患者认知功能下降,一定程度上影响了患者的预后,不利于患者康复。

Objective To analyze the effect of non-rapid eye movement sleep disorder(NREM)on cognitive function in patients with cerebrovascular disease and its correlation.Methods The clinical treatment of 120 patients with cerebrovascular disease who received treatment in our hospital from December 2018 to December 2020 was retrospectively analyzed,and they were grouped according to the sleep disorders.The control group(n=60)were patients without non-REM sleep disorder,and the observation group(n=60)were patients with non-REM sleep disorder.Polysomnography and cognitive function(MOCA)score were compared between the two groups.Results Compared with the control group,the executive function,memory,attention,orientation,verbal fluency and total SCORE of MoCA were significantly lower in the observation group.Compared with the control group,the observation group had longer duration of SOL and NREMS1 sleep and more WUT;The sleep duration of SE,NREM S2,NREM S3+S4 and TST were less(P<0.05).Spearman correlation analysis showed that the total score of MOCA and attention in the observation group were positively correlated with the total sleep time in MREM S3+S4 stage,the memory was negatively correlated with the total sleep time in MREM S3+S4 stage,and the executive function and orientation were positively correlated with the total sleep time in MREM S2 stage(P<0.05).Conclusion NREM sleep disorder can lead to the decline of cognitive function in cerebrovascular patients,which affects the prognosis of patients to some extent and is not conducive to their recovery.