摘要
The Polycomb group(PcG) proteins are a family of chromatin regulators and critical for the maintenance of cellular identity. The PcG machinery can be categorized into at least three multi-protein complexes, namely Polycomb Repressive Complex 1(PRC1), PRC2, and Polycomb Repressive De UBiquitinase(PR-DUB).Their deregulation has been associated with human cancer initiation and progression. Here we review the updated understanding for Pc G proteins in transcription regulation and DNA damage repair and highlight increasing links to the hallmarks in cancer. Accordingly, we discuss some of the recent advances in drug development or strategies against cancers caused by the gain or loss of PcG functions.
基金
supported by the National Key Research and Development Program (2017YFA0504102)
the National Natural Science Foundation of China (81772676, 31970579)
the Natural Science Foundation of Tianjin Municipal Science and Technology Commission (18JCJQJC48200)
Key Research Project of Tianjin Education Commission (2020ZD13)
Open grant from the Chinese Academy of Medical Sciences (157-Zk19-02 and Z20-04)
the Talent Excellence Program from Tianjin Medical University and Research Project of Tianjin Education Commission。
