1,3,2-氧氮磷杂环戊烷衍生物(Ⅱ)——2-二乙氨基-3-取代甲酰基-1,3,2-氧氮磷杂环戊烷衍生物的合成及其性质研究

1, 3,2-Oxazaphospholidine Derivatives(Ⅱ)——Studies on Synthesis and Properties of 2-Diethylamino 3-Substituted Formyl-1,3,2-Oxazaphospholidines

用六乙基亚磷酰胺与N-(β-羟基乙基)取代甲酰胺进行成环反应,合成了一系列新的有机磷杂环化合物,2-二乙氨基-3-取代甲酰基-1,3,2-氧氮磷杂环戊烷,然后与硫作用生成2-硫逐代衍生物,亦可不经分离一步完成上述反应。

A series of new 2-diethylamino 3-substituted formyl-1,3,2-oxazaphospho-lidine derivatives (Ⅰ) have been prepared by the reaction of tris (diethylamino) phosphine with N-(β-hydroxyethyl) substituted amides. When (Ⅰ) was refluxed with sulfur in benzene, its 2-thione derivative (Ⅱ) was obtained. Compound(Ⅱ) can also be synthesized directly in one pot without the separation and purification of intermediate (Ⅰ). The IR, 1HNMR and MS spectra of these compounds have been discussed.