卤代哒嗪酮氟代反应的研究

Studies on Fluorination of Halopyridazinones

前文报道了氟代哒嗪二酮化合物的合成及生理活性,其合成路线较长,收率较低。本文探讨在非质子极性溶剂中氯代哒嗪酮与氟化钾的反应,在不同温度下,将4,5-二氯-1-芳基-6(1H)-哒嗪酮和氟化钾反应,可得到4-氟-5-氯-1-芳基-6(1H)-哒嗪酮(参见反应式).

This article reports a new method for preparing 4-fluoro-1,2-dihydro-pyridazinedione and the reaction of 4,5-dichloro-1-aryl-6(1H)-pyridazinones with KF in aprotic polar solvent. Ten new compounds of 4-fluoro-5-chloro-1-aryl-6(1H)-pyridazinones have been prepared.