糖尿病合并脓毒症研究进展

Research progress of diabetes complicated with sepsis

糖尿病会造成机体系统性损伤,导致免疫功能下降,易并发严重感染。感染时宿主反应失调可导致脓毒症,其病情凶险,患者常在短时间内出现严重器官功能障碍甚至死亡。随着世界范围内糖尿病患病率的急剧上升,糖尿病合并脓毒症的患者数量也快速增加。因此,增加对这2种疾病之间的相互关联和影响的认识对临床救治有十分重要的意义及迫切性。本文就糖尿病与脓毒症在流行病学、总体结局、系统损害及发病机制4个方面的进展进行综述。

Diabetes can cause systemic damage to the body,resulting in a decline in immune function,which is prone to serious infection. Sepsis can be caused by host reaction disorder during infection,which is very dangerous,and patients often suffer from severe organ dysfunction or even death within a short period of time. With a sharp increase in the prevalence of diabetes worldwide,the number of patients with diabetes complicated with sepsis has also increased rapidly. Therefore,it is of great significance and urgency to increase the understanding of the correlation and influence between these two diseases for clinical treatment. This article reviews the progress of diabetes and sepsis in epidemiology,general outcome,systemic damage,and pathogenesis.