克服肿瘤缺氧增效光动力治疗的研究进展

Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy

光动力疗法(photodynamic therapy,PDT)因其高安全性已广泛应用于临床。PDT过程具有高度氧依赖性,而缺氧作为实体肿瘤的特征,显著中和了PDT疗效,限制其在抵抗实体肿瘤上的应用。近年来,许多策略都致力于克服肿瘤缺氧这一"致命弱点"。本文综述了不同克服肿瘤缺氧的方法在增效PDT方面的最新进展。

Photodynamic therapy(PDT) has been widely used in clinic due to its high safety. The PDT process is highly oxygen-depended,however,hypoxia,as a characteristic of solid tumors,significantly neutralizes the PDT efficacy and limits its application in resisting solid tumors. In recent years,tremendous strategies have been devoted to overcoming the “fatal weakness”,tumor hypoxia. In this paper,the latest progress of overcoming tumor hypoxia in enhancing the PDT efficacy are reviewed.