我院2019-2020年氟比洛芬酯注射液用药合理性分析

Analysis on the rationality of flurbiprofen axetil injection in our hospital from 2019 to 2020

目的分析氟比洛芬酯注射液在住院患者中的用药合理性,为临床合理用药和制定科学管理方案提供参考。方法调取医院2019年1月-2020年12月住院患者的氟比洛芬酯注射液临床使用情况,对其适应证、用法用量、配伍溶媒等项目进行分析。结果调查期间共计4 186例患者使用了氟比洛芬酯注射液,使用人数排名前3位的科室依次为骨科、整形手外科和普外科。其中41.23%的患者存在超适应证用药。绝大多数患者的给药频次为每日1次,且超过80%的患者可选择口服给药,与说明书不符。用药禁忌占9.13%,年龄<14岁的儿童占4.20%,老年用药未从小剂量开始占3.49%。5.95%的病历与存在相互作用的药物联合用药。7.29%的病历与其他非甾体抗炎药合并用药。结论氟比洛芬酯超说明书用药情况普遍,药品生产企业应尽早完善药品说明书,临床药师应加大干预力度、多与临床医师沟通,为医师提供合理用药指导,促进氟比洛芬酯注射液在临床更加安全、合理及有效的应用。

AIM To investigate the rationality of flurbiprofen axetil injection in inpatients, so as to provide reference for clinical rational drug use and scientific management plan. METHODS The clinical application of flurbiprofen axetil injection from inpatients in hospital from January 2019 to December 2020 was collected for statistics and analysis of the indications, usage, dosage, solvents and other items. RESULTS During the investigation, a total of 4 186 medical records of flurbiprofen axetil injection were collected, and the top three departments were orthopedics, plastic surgery and general surgery. The 41.23% of the medical records had super indications. The vast majority of medical records were given once a day, and more than 80% of medical records chose oral administration, which did not conform to the instructions. The 9.13% of medical records had contraindications. The 4.20% of medical records were used for children under 14 years of age. The 3.49% of the elderly did not start from the low dose. The 5.95% of medical records were combined with drugs which existing interactions. The 7.29% of medical records were combined with other nonsteroidal antiinflammatory drugs. CONCLUSION Off-label use of flurbiprofen axetil injection is common, manufacturers should improve drug instructions as soon as possible. The clinical pharmacists should intensify intervention efforts, communicate more with doctors, and provide guidance to doctors in rational drug use, so as to promote the safe, reasonable and effective application of flurbiprofen axetil injection in clinical practice.