心律失常患者应用胺碘酮联合美托洛尔的临床效果及对患者不良反应的影响

Effects of Amiodarone Combined with Metoprolol in the Treatment of Patients with Arrhythmia and Its Effect on Adverse Reactions

目的探讨心律失常患者应用胺碘酮联合美托洛尔的临床效果及对患者不良反应的影响。方法选取2018年3月至2020年3月沈阳市辽中区人民医院收治的快速心律失常患者86例作为研究对象,随机分为对照组与观察组,各43例。对照组给予胺碘酮治疗,观察组给予胺碘酮联合美托洛尔治疗。比较两组患者心率、收缩压、舒张压、临床疗效、心功能指标水平及不良反应发生情况。结果治疗前两组患者心率、收缩压、舒张压比较差异无统计学意义(P>0.05);治疗后观察组心率、收缩压、舒张压明显低于对照组(P<0.05)。观察组治疗疗效明显高于对照组(P<0.05)。治疗前两组患者左心室舒张末期内径(LVDD)、左心室收缩末期内径(LVSD)以及左心室收缩功能(LVSF)水平比较差异无统计学意义(P>0.05);治疗后观察组LVDD、LVSD水平明显低于对照组,LVSF水平明显高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率明显低于对照组(P<0.05)。结论对快速心律失常患者应用胺碘酮联合美托洛尔治疗可有效提高临床疗效,促进心功能改善,使患者心率以及血压水平尽快恢复到正常范围,并能进一步减少药物不良反应对患者造成的影响。

Objective To investigate the clinical effect of amiodarone combined with metoprolol on patients with arrhythmia and its effect on adverse reactions.Methods A total of 86 patients with arrhythmia admitted to People’s Hospital of Liaozhong District from March 2018 to March 2020 were selected as the research objects and were randomly divided into a control group and an observation group,with 43 cases in each group.The control group was treated with amiodarone and the observation group was treated with amiodarone combined with metoprolol.The heart rate,systolic blood pressure,diastolic blood pressure,clinical efficacy,cardiac function index levels and adverse reactions were compared between the 2 groups.Results There was no significant difference in heart rate,systolic blood pressure,diastolic blood pressure between the 2 groups before treatment(P>0.05).After treatment,the heart rate,systolic blood pressure,and diastolic blood pressure of the observation group were significantly lower than those of the control group(P<0.05).The therapeutic effect of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in left ventricular end diastolic diameter(LVDD),left ventricular end systolic diameter(LVSD),and left ventricular systolic function(LVSF)levels before treatment between the 2 groups of patients(P>0.05);after treatment,the level of LVDD and LVSD in the observation group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Amiodarone combined with metoprolol in the treatment of arrhythmia patients can effectively enhance the therapeutic effect,promote the improvement of cardiac function,restore the heart rate and blood pressure level to normal range as soon as possible,and further reduce the influence of adverse drug reactions on patients.