认知行为干预联合坦索罗辛治疗良性前列腺增生症患者夜尿症的临床效果观察

Clinical effect of cognitive behavioral intervention combined with tamsulosin on the treatment of nocturia in patients with benign prostatic hyperplasia

目的观察认知行为干预联合坦索罗辛治疗良性前列腺增生症(BPH)患者夜尿症的临床效果。方法选取2016年1月至2019年12月在开滦总医院泌尿外科门诊确诊为BPH的患者230例为研究对象。采用随机数字表分为联合治疗组(115例)和坦索罗辛组(115例)。坦索罗辛组口服盐酸坦索罗辛缓释胶囊治疗;联合治疗组在口服盐酸坦索罗辛缓释胶囊的基础上给予认知行为干预治疗。于治疗前、治疗1、3个月后分别对夜尿次数、生活质量评分进行评价比较。结果治疗3个月后联合治疗组夜尿次数少于坦索罗辛组,治疗3个月后与治疗前夜尿次数差值大于坦索罗辛组[(1.7±0.5)次比(3.2±1.0)次、(2.6±0.8)次比(1.6±1.0)次],差异均有统计学意义(均P <0.05)。治疗1、3个月后,联合治疗组生活质量评分低于坦索罗辛组,治疗3个月后与治疗前生活质量评分差值大于坦索罗辛组[(3.9±1.4)分比(4.1±1.2)分、(2.8±1.1)分比(3.2±1.0)分、(2.5±1.2)分比(1.4±1.0)分],差异均有统计学意义(均P <0.05)。结论认知行为干预联合坦索罗辛治疗能有效减少良性前列腺增生症患者夜尿次数,提高患者生活质量。

Objective To observe the clinical effect of cognitive behavioral intervention combined with tamsulosin on the treatment of nocturia in patients with benign prostatic hyperplasia( BPH). Methods From January 2016 to December 2019,230 patients diagnosed as BPH in Department of Urology Surgery,Kailuan General Hospital were selected. They were randomly divided into combined treatment group( 115 cases) and tamsulosin group( 115 cases). The tamsulosin group was treated with tamsulosin hydrochloride sustained-release capsules orally and the combined treatment group was treated with cognitive behavioral intervention based on tamsulosin hydrochloride sustained-release capsules orally. The frequency of nocturia and the score of quality of life were evaluated and compared before treatment,1 month after treatment and 3 months after treatment. Results After3 months of treatment,the frequency of nocturia in the combined treatment group was less than that in the tamsulosin group,and the difference in frequency of nocturia between 3 months after treatment and before treatment in the combined treatment group was higher than that in the tamsulosin group[( 1. 7 ± 0. 5) times vs( 3. 2 ± 1. 0) times,( 2. 6 ± 0. 8) times vs( 1. 6 ± 1. 0) times]( both P < 0. 05). After 1 month and 3 months of treatment,the score of quality of life in the combined treatment group was lower than that in the tamsulosin group,and the difference in the score of quality of life between 3 months after treatment and before treatment in the combined treatment group was higher than that in the tamsulosin group [( 3. 9 ± 1. 4) vs( 4. 1 ± 1. 2),( 2. 8 ± 1. 1) vs( 3. 2 ± 1. 0),( 2. 5 ± 1. 2) vs( 1. 4 ± 1. 0) ]( all P < 0. 05). Conclusion Cognitive behavioral intervention combined with tamsulosin can effectively reduce the frequency of nocturia and improve the quality of life of patients with BPH.