重复经颅磁刺激治疗耐药性癫痫的有效性及安全性(附4例报告)

Efficacy and safety of repetitive transcranial magnetic stimulation in treating drug resistant epilepsy (report of 4 cases)

目的探讨重复经颅磁刺激(rTMS)治疗耐药性癫痫患者的有效性及安全性。方法回顾性分析4例接受rTMS治疗的耐药性癫痫患者的临床资料,观察其治疗效果及不良反应。结果本组4例患者中3例癫痫患者经rTMS治疗后癫痫发作频率降低50%以上,1例癫痫合并偏头痛患者在接受rTMS治疗后癫痫发作没有明显减少但偏头痛发作消失,4例患者均未出现不良反应。结论 rTMS是一种潜在的耐药性癫痫的治疗手段,最佳的治疗参数及便携式经颅磁刺激仪器在未来应该得到更多的重视及研究。

Objective To investigate the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS) in treating patients with drug resistant epilepsy. Methods The clinical data of 4 patients with drug resistant epilepsy treated with rTMS were retrospectively analyzed. And the therapeutic effects and adverse reactions were observed. Results Among 4 patients, the frequency of epileptic seizures decreased by more than 50% after rTMS treatment in 3 epileptic patients, one epileptic patient complicated with migraine had no significant reduction of seizures but migraine attacks disappeared after rTMS treatment. There were no adverse reactions in 4 patients. Conclusions rTMS is a potential treatment for drug resistant epilepsy. The optimal treatment parameters and portable transcranial magnetic stimulation instruments should be paid more attention to and studied in the future.