低强度脉冲式超声波机械力生物链内源性干细胞激活与功能修复的研究进展

Progress on the activation of endogenous stem cells and functional repair in LIPUS mechanotransduction

近年来,以低强度脉冲式超声波(LIPUS)为代表的机械力治疗手段已被广泛用于康复医学、骨折修复、神经损伤修复、泌尿系统疾病等领域。目前研究表明,LIPUS可能通过激活内源性干细胞参与组织修复,但是机械力如何通过生物链的转化而激活干细胞的具体机制尚不明确,因此对机械力生物链传导过程的进一步探索有助于揭示LIPUS的作用机制并为后续的研究与临床应用提供帮助。

In recent years, mechanical therapies represented by low-intensity pulsed ultrasound(LIPUS) have been widely used in rehabilitation medicine, fracture repair, nerve injury repair, urinary system diseases and other fields. Current studies have shown that LIPUS may participate in tissue repair by activating endogenous stem cells, but the specific mechanism by which mechanical force activates stem cells through the transformation of the biological chain is still unclear. Therefore, further exploration of the conduction process of mechanotransduction will help to reveal the mechanism of LIPUS and provide reference for subsequent researches and clinical applications.