青霉素发酵过程控制系统设计

Design of Penicillin Fermentation Process Control System

青霉素生产是典型的间歇过程,它的发酵过程呈现时变性和非线性强的特征,测量量和被控量间之间相互耦合,若操作稍有不当,发酵可能会失败。针对青霉素发酵过程的工艺流程,为了进一步提高青霉素发酵效率并对发酵过程进行实时在线监控,提高发酵过程自动化管理水平,设计出一套青霉素发酵过程自动控制系统。该控制系统从发酵前期准备到发酵实现实施全流程精细化管理,并利用趋势分析方法,通过时间窗口内的参数拟合找出参数在该时段内的趋势变化,实现对菌体生长各阶段的实时监测。该发酵控制系统已经在实际工业中得到应用,效果良好。

Penicillin production is a typical batch process.Its fermentation process is time⁃varying and nonlinear.The meas⁃ured quantity and controlled quantity are coupled with each other.If it is operated improperly,the fermentation will fail.According to the process of penicillin fermentation,in order to further improve the efficiency of penicillin fermentation,real⁃time online moni⁃toring of the fermentation process and improve the level of automatic management of the fermentation process,an automatic control system of penicillin fermentation process was designed.The control system realized the fine management from the preparation of fermentation to the whole fermentation process,and used the trend analysis method to find out the trend change of parameters in the period through the parameter fitting in the time window,so as to realize the real⁃time monitoring of each stage of the growth of bacteria.The fermentation control system has been applied in practical industry,and the effect is good.