药物经济学评价中患者用药依从性的识别、测量与估值

Identification,Measurement and Evaluation of Patients'Drug Compliance in Pharmacoeconomic Evaluation

分析患者用药依从性的定义与分类、指标与测量方法、对效果和成本的影响,讨论将依从性纳入药物经济学评价的方法和流程。结果显示:在药物经济学评价纳入依从性时,应明确依从性的定义;依从性对效果的影响复杂,在分析时可参考三个因素——患者不依从的形式、疾病的病理生理过程和药物代谢动力学特征;在考察依从性对成本的影响时,需结合临床效果的变化具体分析。

This paper analyzes the definition and classification,indicators and measurement methods of patients'drug compliance,and their effects on effectiveness and cost,and discuss the methods and processes of bringing compliance into pharmacoeconomic evaluation.The results show that when compliance is included in pharmacoeconomic evaluation,the definition of compliance should be clearly defined;and due to the influence of compliance on the effectiveness is complex,we can refer to three factors in the analysis-the form of patient non-compliance,the pathophysiological process of the disease and the characteristics of pharmacokinetics;when investigating the effect of compliance on cost,we need to analyze the changes of clinical effect.