血清尿酸、超敏C反应蛋白水平与急性脑梗死后认知功能的关系

Correlations between serum uric acid,high sensitivity C-reactive protein levels and cognitive function after acute cerebral infarction

目的分析血清尿酸(BUA)及超敏C反应蛋白(hs-CRP)表达与急性脑梗死(ACI)后轻度认知功能障碍的相关性。方法前瞻性纳入住院治疗的150例ACI患者为研究对象,全部患者均于病情稳定后评价认知功能情况,并根据认知功能障碍情况将患者分为认知功能障碍组和非认知功能障碍组。统计患者认知功能障碍发生情况,研究对象在入院时均接受血清BUA、hs-CRP水平检测,分析血清BUA、hs-CRP与ACI后轻度认知功能障碍的相关性。结果入院后发生轻度认知功能障碍的患者66例(44.00%),患者入院时血清BUA水平、hs-CRP水平高于非认知功能障碍组,差异有统计学意义(P<0.05)。简易智能精神状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分与血清BUA、hs-CRP水平均呈负相关(rs<0,P<0.05)。结论血清BUA、hs-CRP水平与ACI后轻度认知功能障碍有一定联系,随着血清BUA、hs-CRP水平升高,患者发生轻度认知障碍风险也相应增高。

Objective To analyze the correlations between the expressions of serum uric acid(BUA),high sensitivity C-reactive protein(hs-CRP)and mild cognitive dysfunction after acute cerebral infarction(ACI).Methods A total of 150 patients with ACI who were hospitalized were retrospectively included as the research subjects,the cognitive function of all patients was evaluated after their condition was stable,and the patients were divided into cognitive dysfunction group and non-cognitive dysfunction group according to the condition of cognitive dysfunction.The occurrence of cognitive dysfunction in patients was counted and all patients received the detection of serum BUA and hs-CRP levels on admission,the correlations between serum BUA,hs-CRP and mild cognitive dysfunction after ACI were analyzed.Results A total of 66 had mild cognitive dysfunction,accounting for 44.00%.The levels of serum BUA and hs-CRP in the cognitive dysfunction group on admission were higher than those in the non-cognitive dysfunction group(P<0.05).Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA)scores were negatively corrected with serum BUA,hs-CRP levels(rs<0,P<0.05).Conclusion Serum BUA and hs-CRP levels are associated with mild cognitive dysfunction after ACI.With the increase of serum BUA and hs-CRP levels,the risk of mild cognitive dysfunction in patients is increased.