急性心肌梗死患者血栓弹力图与常规凝血试验指标的相关性分析

Analysis in correlations between thromboelastography and routine coagulation test indexes in patients with acute myocardial infarction

目的分析急性心肌梗死患者常规凝血试验指标与血栓弹力图参数的相关性。方法选取100例急性心肌梗死患者为研究组,另选取同期100例健康志愿者为对照组。比较2组常规凝血试验指标及血栓弹力图参数,并分析二者间的相关性。结果研究组凝血酶时间长于对照组,纤维蛋白原水平高于对照组,差异有统计学意义(P<0.05)。研究组凝血反应时间(R值)、血凝块形成时间(K值)短于对照组,血凝块形成速率(α值)、血凝块形成后最大振幅(MA值)高于对照组,差异有统计学意义(P<0.05)。凝血酶原时间、活化部分凝血活酶时间与血栓弹力图R值呈正相关,与K值无相关性,与α值、MA值呈负相关;凝血酶时间、纤维蛋白原与K值呈负相关,与α值、MA值呈正相关,同时纤维蛋白原与R值呈负相关。结论急性心肌梗死患者的常规凝血试验指标与血栓弹力图参数存在显著相关性,在血栓弹力图基础上结合常规凝血试验指标的指导效果更好。

Objective To analyze the correlations between routine coagulation test indexes and thromboelastography parameters in patients with acute myocardial infarction.Methods Totally 100 patients with acute myocardial infarction were selected as study group,while another 100 healthy volunteers in the same period were selected as control group.The routine coagulation test indexes and thromboelastography parameters were compared between two groups,and the correlation between the two methods was analyzed.Results The thrombin time of the study group was significantly longer,and fibrinogen level of the study group was significantly higher than that of the control group(P<0.05).The coagulation reaction time(R value)and clot formation time(K value)of the study group were significantly shorter than those of the control group,while the clot formation rate(α value)and the maximum amplitude(MA)after clot formation were higher than those in the control group(P<0.05).Prothrombin time and activated partial thromboplastin time were positively correlated with R value and negatively correlated with MA value andαvalue of thromboelastography,but had no correlations with K value.Thrombin time and fibrinogen were negatively correlated with K value and positively correlated with α value and MA value,and at the same time,fibrinogen was negatively correlated with R value.Conclusion There are significant correlations between routine coagulation test indexes and thromboelastography parameters in patients with acute myocardial infarction.The guidance effect of combining routine coagulation test indexes with thromboelastography is better.