新型冠状病毒肺炎早期检测指标的危重症预警价值分析

Early warning value analysis of early detection indicators of COVID-19 in critical disease

目的:分析新型冠状病毒肺炎早期检测指标的危重症预警价值。方法:比较新型冠状病毒肺炎危重和非危重、糖尿病和非糖尿病早期的血糖、中性粒细胞、C反应蛋白、血清淀粉样蛋白A、唾液酸、球蛋白、胱抑素C、肌酸激酶、肌酸激酶同工酶、α羟丁酸脱氢酶、乳酸脱氢酶、乳酸脱氢酶同工酶、血清白蛋白等指标。结果:危重组和非危重组性别、年龄差异无统计学意义(P>0.05),危重组和非危重组间中性粒细胞、血清淀粉样蛋白A、唾液酸、肌酸激酶同工酶、α羟丁酸脱氢酶、乳酸脱氢酶、乳酸脱氢酶同工酶、血清白蛋白差异均有统计学意义(P<0.05~P<0.01)。血糖、C反应蛋白、球蛋白、胱抑素C、肌酸激酶差异均无统计学意义(P>0.05)。糖尿病组和非糖尿病组性别、年龄差异无统计学意义(P>0.05),2组间血糖和血清白蛋白差异有统计学意义(P<0.01和P<0.05),2组间中性粒细胞、C反应蛋白、血清淀粉样蛋白A、唾液酸、球蛋白、胱抑素C、肌酸激酶、肌酸激酶同工酶、α羟丁酸脱氢酶、乳酸脱氢酶、乳酸脱氢酶同工酶差异均无统计学意义(P>0.05)。结论:炎性指标中性粒细胞、血清淀粉样蛋白A、唾液酸和脏器损伤指标肌酸激酶同工酶、α羟丁酸脱氢酶、乳酸脱氢酶、乳酸脱氢酶同工酶等增高和营养指标血清白蛋白降低是危重病例的早期预测指标,高血糖所导致的营养状况降低对COVID-19的严重程度有重要影响。

Objective:To analyze the early warning value of early detection indicators of corona virus disease 2019(COVID-19)in critical disease.Methods:The patients with COVID-19 were divided into the critical group and non-critical group,and diabetic group and non-diabetic group.The levels of early blood glucose,neutrophils,C reactive protein,serum amyloid A,sialic acid,globulin,cystatin C,creatine kinase,creatine kinase isoenzyme,α-hydroxybutyrate dehydrogenase,lactate dehydrogenase,lactate dehydrogenation enzyme isozyme,serum albumin and other indicators were compared between the critical group and non-critical group,and between diabetic group and non-diabetic group.Results:The differences of the gender and age between critical group and non-critical group were not statistically significant(P>0.05).The differences of the levels of neutrophils,serum amyloid A,sialic acid,creatine kinase isoenzyme,α-hydroxybutyrate dehydrogenase,lactate dehydrogenase,lactate dehydrogenase isoenzyme and serum albumin between critical group and non-critical group were statistically significant(P<0.05 to P<0.01),and there was no statistical significance in the levels of blood glucose,C reactive protein,globulin,cystatin C and creatine kinase between two groups(P>0.05).There was no statistical significance in the gender and age between the diabetic group and non-diabetic group(P>0.05),the differences of the levels of blood glucose and serum albumin between two groups were statistically significant(P<0.01 and P<0.05),and the differences of the levels of neutrophils,C-reactive protein,serum amyloid A,sialic acid,globulin,Cystatin C,creatine kinase,creatine kinase isoenzyme,α-hydroxybutyrate dehydrogenase,lactate dehydrogenase and lactate dehydrogenase isoenzyme between two groups were not statistically significant(P>0.05).Conclusions:The inerease of neutrophils,serum amyloid A,sialic acid of inflammatory indexes,creatine kinase isoenzyme,α-hydroxybutyrate dehydrogenase,lactate dehydrogenase,lactate dehydrogenase isoenzyme and decrease of the albumin are the early predictors of critical disease.The decrease of nutritional status caused by hyperglycemia has an important impact on the severity of COVID-19.