丙种球蛋白结合高压氧对病毒性脑炎患儿的康复效果

Effect of hyperbaric oxygen combined with r-globulin on the rehabilitation of viral encephalitis children

目的:探究高压氧结合丙种球蛋白对病毒性脑炎(VE)患儿的康复效果及对β-内啡肽(β-EP)、髓鞘碱性蛋白(MBP)和心肌酶谱水平的影响。方法:110例VE患儿采用随机数字表法分为观察组55例和对照组55例。对照组患儿给予丙球蛋白进行治疗,观察组给予高压氧联合丙球蛋白进行治疗。观察2组患儿的临床疗效、临床症状缓解时间,β-EP、MBP及心肌酶谱水平,以及后遗症的发生率。结果:观察组患儿的治疗有效率为90.91%,显著高于对照组患儿72.73%(P<0.01);观察组患儿的退热、头痛、恶心呕吐以及意识清醒缓解时间等方面均显著短于对照组(P<0.01);另外,治疗后,2组患儿血清中的β-EP和MBP水平均显著下降(P<0.01),且观察组病人水平显著低于对照组(P<0.01);治疗后,2组病人血清中LDH、CK、CK-MB及AST水平均显著降低(P<0.01),并且观察组病人水平显著低于对照组(P<0.01);观察组患儿后遗症发生率仅为9.01%且显著低于对照组的23.64%(P<0.05)。结论:高压氧结合丙种球蛋白能够有效治疗病毒性脑炎患儿,通过降低患儿β-EP、MBP及心肌酶谱水平,改善病人神经功能,降低后遗症的发生率,值得在临床上推广。

Objective:To explore the effects of hyperbaric oxygen combined with r-globulin on the rehabilitation and levels ofβ-endorphin(β-EP),myelin basic protein(MBP)and myocardial enzyme spectrum in children with viral encephalitis(VE).Methods:One hundred and ten children with VE were divided into the observation group and control group using random number table method(55 cases in each group).The control group was treated with r-globulin,while the observation group was treated with hyperbaric oxygen combined with r-globulin.The clinical efficacy,clinical symptom,relief time,levels ofβ-EP,MBP and myocardial enzyme spectrum,and incidence rate of sequelae were observed in two groups.Results:The therapeutic efficiency in observation group(90.91%)was significantly higher than that in control group(72.73%)(P<0.01).The remission time of fever,headache,nausea and vomiting and consciousness in observation group were significantly lower than those in control group(P<0.01).After treatment,the serum levels ofβ-EP and MBP in two groups significantly decreased(P<0.01),and which in observation group were significantly lower than those in control group(P<0.01).After treatment,the serum levels of LDH、CK、CK-MB and AST in two groups significantly decreased(P<0.01),and which in observation group were significantly lower than those in control group(P<0.01).The incidence rate of sequelae in observation group(9.01%)was significantly lower than that in control group(23.64%)(P<0.05).Conclusions:Hyperbaric oxygen combined with r-globulin can effectively treat the VE.The neurologic function can be improved,and the incidence rate of sequelae can be reduced by decreasing the levels ofβ-EP,MBP and myocardial enzyme in VE children.It is worthy of clinical promotion.